Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Whitespotted Eagle Rays Have a Broader Diet Than Previously Thought

With mighty jaws and plate-like teeth, the whitespotted eagle ray (Aetobatus narinari) can pretty much crunch on anything.

2 Aug 2023

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Bioprocessing Breakthrough: Xheme Non-Toxic, Multifunctional Additive Eliminates Oxidative Stress

Oxidative stress, caused by an imbalance of free radicals and antioxidants, regularly reduces the yield of pharmaceuticals and therapeutics produced via bioprocessing by about 10-15%. Now, Xheme, Inc.'s Xheme Multifunctional Additive (XMA), a programmable non-toxic nanoporous microparticle, has demonstrated the ability to significantly reduce or eliminate the damage of oxidative stress in bioprocessing conditions.

25 Jul 2023

Unraveling the Link Between High Body Temperature and Increased Viral Resistance

Researchers from The University of Tokyo unravel the connection between high body temperature and increased viral resistance.

21 Jul 2023

Researchers Make Breakthrough in Fight Against Familial Hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world.

21 Jul 2023

Uncovering New Insights into Virus Self-Assembly

Griffith University researchers were instrumental in controlling the way viruses are assembled by using DNA “origami” templates.

18 Jul 2023

Scientists Discover Specific Genes Involved in Rare, Life-Threatening Heart Disease

By identifying genes in patients and testing their effects in fruit flies, researchers from Sanford Burnham Prebys have found new genes that contribute to hypoplastic left heart syndrome (HLHS), a rare, life-threatening heart disease that occurs in infants.

18 Jul 2023

Next Step in Sartorius Partnership Finalized: Several Subsales and Distribution Agreements as Well as R&D Project Agreements Have Been Signed

During May and June 2023 several sub-sales and distribution agreements were signed between Sartorius and BICO companies CELLINK, Advanced BioMatrix (ABM) and Dispendix.

From BICO 5 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Camena Bioscience Closes $10m Series A Financing as Demand for DNA Synthesis Technology Increases

Camena Bioscience, a synthetic biology company providing genes to the pharmaceutical and biotechnology industries, today announced it has closed a $10m Series A financing round, led by Mercia.

4 Jul 2023

Theta Supercomputer Used To Find Essential Factors That Control Structural Change of HIV Protease

Every disease has a protein basis. For some diseases, like HIV, changes in protein structure are critical for how the virus infects a person's cells.

20 Jun 2023

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Metrion Biosciences Ltd (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr Steve Jenkinson as Vice President, Drug Discovery and Safety Assessment.

12 Jun 2023

Research Uncovers the Biology Underpinning a Rare Genetic Mutation Linked to Painlessness

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL.

24 May 2023

An In-Depth Analysis of the Human Genome Using the New “Pangenome”

The Human Genome Project, which began in April 2003, contributed to the revolutionization of biomedical research by giving researchers a reference map that allowed them to scan DNA sequences for genetic clues about the causes of a variety of diseases.

16 May 2023

New Method for Analyzing Protein Crystals Could Open Up Applications for Drug Discovery

A new method for analyzing protein crystals – developed by Cornell researchers and given a funky two-part name – could open up applications for new drug discovery and other areas of biotechnology and biochemistry.

12 May 2023

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

11 May 2023

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

8 May 2023

Drug Discovery News and Research

Further Reading

Whitespotted Eagle Rays Have a Broader Diet Than Previously Thought

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

Bioprocessing Breakthrough: Xheme Non-Toxic, Multifunctional Additive Eliminates Oxidative Stress

Unraveling the Link Between High Body Temperature and Increased Viral Resistance

Researchers Make Breakthrough in Fight Against Familial Hypercholesterolemia

Uncovering New Insights into Virus Self-Assembly

Scientists Discover Specific Genes Involved in Rare, Life-Threatening Heart Disease

Next Step in Sartorius Partnership Finalized: Several Subsales and Distribution Agreements as Well as R&D Project Agreements Have Been Signed

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

Camena Bioscience Closes $10m Series A Financing as Demand for DNA Synthesis Technology Increases

Theta Supercomputer Used To Find Essential Factors That Control Structural Change of HIV Protease

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Research Uncovers the Biology Underpinning a Rare Genetic Mutation Linked to Painlessness

An In-Depth Analysis of the Human Genome Using the New “Pangenome”

New Method for Analyzing Protein Crystals Could Open Up Applications for Drug Discovery

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Reducing Intracellular Ice Formation in Advanced Cell Models

3D Genome Mapping may Lead to Targeted Therapeutic Options for Ependymoma

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