Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Scientists develop a new gene biomarker identification method for toxicity testing

Companies like agrochemicals must check extensively for possible toxicity when they develop new products, before they can obtain regulatory approval.

21 Dec 2020

Researchers discover protein that may trigger lung scarring

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs.

18 Dec 2020

Researchers develop a diagnostic tool for amyotrophic lateral sclerosis

Infrared analyses of neuronal proteins provide information on molecular changes in patients with ALS. This helps to verify their diagnosis.

10 Dec 2020

Researchers demonstrate strategy to control chemical reactions using antibodies

Antibodies are remarkable biomarkers: they are the cues that provide us with indications about many diseases and how our immune system counter them. Now a group of scientists from the University of Rome, Tor Vergata (Italy) has found a way to repurpose them so that they can trigger a specific chemical reaction.

8 Dec 2020

Disturbances in the gut microbiome may explain major depressive disorder

Researchers have successfully detected three bacteriophages, 50 fecal metabolites, 47 bacterial species that were considerably more or less abundant in patients with major depressive disorder (MDD) when compared to healthy controls. The study involved 311 individuals.

4 Dec 2020

World’s largest proteomics centre accelerates biomarker discoveries to improve people’s lives

Opened in 2016, Manchester’s Stoller Biomarker Discovery Centre (SBDC) is a globally renowned, multi-million-pound precision medicine research facility.

30 Nov 2020

Novel DNA-based nanogel for targeted delivery of chemotherapeutics

Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells.

19 Nov 2020

New way to predict who will respond to cancer therapies that block Wnt production

Scientists have identified possible means to prognosticate who will respond to cancer therapies that inhibit Wnt production.

16 Nov 2020

Presence of microbes in the lung can modulate lung cancer pathogenesis

Enrichment of the lungs with oral commensal microbes was associated with advanced-stage disease, worse prognosis, and tumor progression in patients with lung cancer.

12 Nov 2020

Unrelated mutations can lead to false positive results in men with advanced prostate cancer

Unrelated mutations, when present in the blood, can lead to false positive results in men with advanced prostate cancer who are undergoing liquid biopsies.

6 Nov 2020

Rapid prognosis of SARS-CoV-2 by MALDI-TOF MS

Gomila et al. recently uploaded a study to the preprint server medRxiv* (November 2020), aiming to utilize MALDI-TOF MS to analyze the sera of patients infected with SARS-CoV-2 in a range of disease severity states.

6 Nov 2020

Why a diet high in flavanols may lower blood pressure

In this interview, AZoLifeSciences speaks to Professor Kuhnle about his latest research which showed that a diet high in flavanols may lower blood pressure.

From University of Reading 28 Oct 2020

Cellular senescence variations may help control health and onset of age-related diseases

Researchers from Kumamoto University, Japan have proposed that cellular senescence variations during the aging process could lead to control of health and onset of age-related diseases.

27 Oct 2020

Dual-chip system for monitoring heart toxicity from breast cancer drugs

Breast cancer is the most commonly occurring cancer for women around the world, and much effort has been spent in the development of therapies to treat this disease.

27 Oct 2020

Researchers identify a promising target for treating chemo-resistant cancer cells

As medical professionals and scientists work to design new therapies for cancer, they come across a range of difficulties.

26 Oct 2020

Study links gut hormone to Parkinson’s dementia

A team of researchers have discovered that a gut hormone, called ghrelin, is a crucial regulator of new nerve cells that form in the adult brain.

26 Oct 2020

Study finds significant link between flavanol consumption and lower blood pressure

People who consume a diet including flavanol-rich foods and drinks, including tea, apples and berries, could lead to lower blood pressure, according to the first study using objective measures of thousands of UK residents' diet.

22 Oct 2020

Key blood marker could offer the most effective treatment for melanoma

An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma.

19 Oct 2020

Scientists identify heart cells responsible for repairing damaged heart after infarction

A global study has discovered the heart cells responsible for repairing the damage induced to this vital organ following infarction.

15 Oct 2020

Immune cell biomarker may help identify patients at risk for graft-versus-host disease

A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D., Ph.D., sheds light on immune cell biomarkers that may reveal which patients are most at risk for graft-versus-host disease (GVHD), a life-threatening condition that can arise after hematopoietic stem cell transplantation (HSCT) for treatment of liquid cancers such as leukemia.

8 Oct 2020