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Study Reveals How Simple Molecules Could Have Formed Early Cell Membranes

Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist? How did these early protocells develop the structural membranes necessary for cells to thrive and assemble into complex organisms?

14 Nov 2024

Discovering New Drug Targets Through Paralog Hopping

Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites.

3 Oct 2024

New AI Model ProteinGenerator Revolutionizes Protein Design with Sequence and Structure Integration

Harnessing deep learning, ProteinGenerator designs diverse proteins with specific properties, offering new avenues for drug development and biotechnology.

2 Oct 2024

Hydrogen Sulfide Plays a Crucial Role in Bacterial Survival

Two crucial biological processes that support the growth of bacteria, particularly pathogenic bacteria like Escherichia coli, are antibiotic resistance and the oxidative stress response.

30 Sep 2024

Study Uncovers Biomarkers for Low Muscle Mass, Offering Insights for Personalized Prevention

Machine learning models to analyze computed tomography (CT) images of the chest and a proteomics approach to determine blood protein biomarkers.

15 Aug 2024

Mitochondrial Phosphate Carrier MIR1: A Key Player in Candida albicans Virulence

This study is led by Professor Yan Wang (School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai, China). Her team found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.

23 May 2024

Rare YKT6 Gene Variants Linked to New Neurological Disorder

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

2 Apr 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

Researchers Reveal Evolutionary Origin of Mysterious Immune System Molecule in Humans

Biological systems can behave as siblings in several ways, including by borrowing something and never giving it back.

31 Jan 2024

Study Elucidates How Amino Acids Turn on Cell Growth Engine

Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions.

22 Dec 2023

Deciphering the Chemistry Behind Antibody Tetramerization

Novel insights into antibody aggregation are anticipated to pave the way for fresh avenues in both research and therapeutic applications.

11 Dec 2023

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

The concept of irreversible inhibitors binding permanently to a target protein has garnered growing interest for potential applications in drug development.

30 Nov 2023

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcription factor with a role in maintaining oxidative stress response. It can be triggered by both redox-dependent and redox-independent pathways.

13 Jun 2023

Revealing an Unanticipated Mechanism for Chaperone-Mediated Ribosome Repair

Researchers have discovered that if oxidative stress destroys protein factories known as ribosomes, repair crews may go in to assist in repairing the damage so that production may restart rapidly.

26 Apr 2023

A Protein Domain Could Lead to New Treatments for COVID-19

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

18 Apr 2023

Specialized Diet Stimulates a Unique Form of Programmed Cell Death

Glioblastoma is the most prevalent kind of adult brain tumor.

10 Apr 2023

Study reveals how chloroplast ATP synthase regulates ATP production in organisms

ATP, the compound essential for the functioning of photosynthetic organisms such as plants, algae, and cyanobacteria, is produced by an enzyme called "chloroplast ATP synthase" (CFoCF1).

22 Feb 2023

New insights into the mechanism underlying the immunomodulatory effects of polyphenols

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

22 Feb 2023

Innovative cancer therapy options with new cell death mechanism

Researchers from The University of Texas MD Anderson Cancer Center have described a previously unrecognized type of cell death called disulfidptosis in a study that was published in Nature Cell Biology.

7 Feb 2023

Discovering H2O2 sensing capacity in plants that control immunity

All aerobic organisms produce the molecule hydrogen peroxide (H2O2). When present in low concentrations, it acts as a crucial secondary signal to control a variety of biological processes, including but not limited to plant-microbe interactions, abiotic stress tolerance, pollen tube growth, root hair formation, leaf cell expansion, and Casparian strip formation.

20 Oct 2022