Cell Biology

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Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Astrocytes modulate balance in neural networks, control decision making

Decision-making during goal-directed behaviors is deliberative process involving different brain areas that considers pros and cons of each option.

8 Dec 2020

Researchers map neuron types comprising the enteric nervous system in mice intestine

Researchers at Karolinska Institutet have succeeded in mapping the neuron types comprising the enteric nervous system in the intestine of mice.

8 Dec 2020

Scientists use advanced methods for investigating structure and interactions of proteins

Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St. Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins -- that is, using advanced methods for investigating the structure and interactions of proteins within larger molecules.

8 Dec 2020

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

A research team has used a novel method that could help resolve the issue of unnecessary genetic changes encountered in the CRISPR-Cas9 technique.

7 Dec 2020

Gene therapy and medication can provide certain beneficial effects of physical exercise

Jose Bianco Moreira from NTNU is now convinced that gene therapy can be used to achieve the positive health benefits of physical exercise.

7 Dec 2020

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

According to a new study, a novel T cell genetically engineered by scientists from The University of Arizona Health Sciences can target and attack pathogenic T cells that are responsible for causing Type 1 diabetes. These latest findings may result in new immunotherapy therapies.

7 Dec 2020

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.

7 Dec 2020

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma, according to findings from a multi-institutional phase I study being presented by Alfred L. Garfall, MD, an assistant professor of Medicine in the division of Hematology-Oncology in the Perelman School of Medicine at the University of Pennsylvania, at the annual American Society of Hematology & Exposition Meeting on Dec. 5 (abstract #180).

7 Dec 2020

Study: Blood type is not associated with effects of plant-based diet on body weight

A study published in the Journal of the Academy of Nutrition and Dietetics by researchers with the Physicians Committee for Responsible Medicine--a nonprofit of 12,000 doctors--debunks the "blood type diet" by finding that blood type was not associated with the effects of a plant-based diet on body weight, body fat, plasma lipid concentrations, or glycemic control.

7 Dec 2020

New method proposed to quantify link between consumption of live microbes and better human health

Many everyday foods--from yogurt and other fermented foods to fresh fruits and vegetables--contain live microorganisms.

7 Dec 2020

Mediterranean diet decreases the likelihood of having another heart attack

A clinical study with 1002 patients with heart disease shows the advantages of a Mediterranean diet compared to a low-fat diet.

7 Dec 2020

Biochemist discovers hidden cellular machinery essential for higher-order life

In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that's essential for all higher order life from yeast to humans.

7 Dec 2020

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes.

7 Dec 2020

CRISPR-based test for COVID-19 provides quick, accurate results

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

7 Dec 2020

Gasdermin E triggers pyroptosis and involved in pathogen-induced coral death

Pyroptosis is a highly inflammatory form of programmed necrotic cell death that acts as a defense mechanism against the infection of bacterial and viral pathogens. Pyroptosis is executed by gasdermin, a family of pore-forming proteins.

7 Dec 2020

Researchers use super-resolution microscopy to study bacterial infection mechanisms

Expansion microscopy, abbreviated as ExM, allows scientists to image cells and their components with a spatial resolution down to 200 nm.

4 Dec 2020

Blackcurrants have beneficial effect on post-meal glucose response

Blackcurrants have a beneficial effect on post-meal glucose response, and the required portion size is much smaller than previously thought, a new study from the University of Eastern Finland shows.

4 Dec 2020

Study explains new associations between Neanderthal DNA and autoimmune diseases

A researcher at the University of Tartu described new associations between Neanderthal DNA and autoimmune diseases, prostate cancer and type 2 diabetes.

4 Dec 2020

Scientists propose a simple model for gene regulation in higher organisms

Although the DNA and its double-helix are some of the most familiar molecules of our time, our knowledge of how cells control what genes they want to express still is rather limited. In order to create, for example, an enzyme, the information that's inscribed in our DNA about this enzyme needs to be transcribed and translated.

4 Dec 2020

Cell Biology

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Astrocytes modulate balance in neural networks, control decision making

Researchers map neuron types comprising the enteric nervous system in mice intestine

Scientists use advanced methods for investigating structure and interactions of proteins

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

Gene therapy and medication can provide certain beneficial effects of physical exercise

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

Study: Blood type is not associated with effects of plant-based diet on body weight

New method proposed to quantify link between consumption of live microbes and better human health

Mediterranean diet decreases the likelihood of having another heart attack

Biochemist discovers hidden cellular machinery essential for higher-order life

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

CRISPR-based test for COVID-19 provides quick, accurate results

Gasdermin E triggers pyroptosis and involved in pathogen-induced coral death

Researchers use super-resolution microscopy to study bacterial infection mechanisms

Blackcurrants have beneficial effect on post-meal glucose response

Study explains new associations between Neanderthal DNA and autoimmune diseases

Scientists propose a simple model for gene regulation in higher organisms

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