Cell Biology

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Mapping Gene Targets of HNF4A and HNF1A in Human Pancreatic Beta Cells and Liver Cells

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells.

26 Jun 2024

CRISPR-Derived Protein Controls Exon Inclusion and Exclusion

The University of Toronto researchers have successfully and precisely controlled the process of RNA splicing by using CRISPR, a bacterial immune defense system.

25 Jun 2024

High-resolution 3D maps of diseased tissues at the subcellular level

Molecular maps from patient tissue samples can be created with subcellular precision using an open-source platform created by researchers in the lab of Nikolaus Rajewsky at the Max Delbrück Center. This allows for in-depth analysis and may improve routine clinical pathology. The research was published in the journal Cell.

25 Jun 2024

Using iPSC-Derived Cardiomyocytes to Uncover Mechanisms of Hypertrophic Cardiomyopathy

Using animals to study heart disease doesn't always translate well to human health outcomes, and human heart cells available for research don't work outside the human body.

25 Jun 2024

AI-Based Approach Revolutionizes Protein Interaction Prediction

Proteins are the building blocks of life, involved in virtually every biological process.

25 Jun 2024

Primitive Endoderm Stem Cells Offer New Hope for Fertility Treatments

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen.

25 Jun 2024

Unlocking the Role of Antisense RNA as a Gene Expression Booster

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

25 Jun 2024

Genetic Influences on Lifespan Variance and Healthspan in Caenorhabditis elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

25 Jun 2024

Small Molecule Restores TERT Levels to Combat Aging-Related Decline

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

24 Jun 2024

Integrated Cellular Map of Heart Fibrosis Unlocks New Treatment Avenues

Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a major cause of heart failure.

24 Jun 2024

New Cold-Sensing Protein Discovery Could Revolutionize Pain Management

The only available treatments for millions of people with chronic pain worldwide frequently involve the use of opioids, which pose the risk of addiction and overdose.

24 Jun 2024

New Gene-Editing Tool Offers More Precision and Flexibility

Researchers at the University of Sydney have created a gene-editing instrument that is more precise and adaptable than the industry standard CRISPR, which has transformed genetic engineering in biotechnology, agriculture, and medicine.

24 Jun 2024

Study Identifies Three Distinct Subtypes of Clear Cell Renal Cell Carcinoma Using Radiomics and Transcriptomics

Using transcriptomics and radiomics data clustering and its association with molecular characteristics, clinical pathologies, and prognosis to define intrinsic subtypes of ccRCC.

24 Jun 2024

Researchers Discover Link Between Ancient Biological Mechanism and Restricted Healthy Hair Growth

University of Manchester scientists have linked one of the ways that cells respond to stressful conditions with restricted healthy hair growth.

22 Jun 2024

3D Cell Cultures Improve Drug Screening Accuracy but Show Lower Efficacy for Anti-Cancer Drugs

The existing knowledge on monolayers and spheroid-based cell cultures, including the constituent compounds, and the difference in efficacy during drug screening, especially for anti-cancer drugs targeting cytoskeletal dynamics and cell cycles.

21 Jun 2024

Detecting Auto-Antibodies for Early Identification of High-Risk COVID-19 Cases

Researchers recently discovered that auto-antibodies against their type 1 interferons, crucial immunological signaling proteins, were present in some COVID-19 patients.

20 Jun 2024

Study Reveals Immune Factors Behind COVID-19 Resistance in Some Individuals

As part of the first-ever COVID-19 human challenge study, researchers from the Wellcome Sanger Institute, University College London (UCL), Imperial College London, the Netherlands Cancer Institute, and their collaborators examined immune responses against SARS-CoV-2 infection in healthy adult volunteers using single-cell sequencing.

20 Jun 2024

Tabulae Paralytica: Mapping Cellular Dynamics in Spinal Cord Injuries

Scientists at EPFL have achieved a significant research milestone in the field of spinal cord injuries-;mapping out the cellular and molecular dynamics of paralysis in unprecedented detail with their open-source project 'Tabulae Paralytica'.

20 Jun 2024

Understanding Collective Cell Behavior in Constrained Environments

Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks.

20 Jun 2024

Single T Cell Population May Hold the Key to Targeted Treatments

Researchers at the University of Cambridge have found that a particular kind of white blood cell known as a regulatory T cell resides in the body as a single, massive population of cells that travel throughout it in search of and repair damaged tissue.

19 Jun 2024