Genomics

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Gene therapy may be a safe and effective single-dose treatment for hypophosphatasia

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10--a gene therapy that replaces a key enzyme found in bone--may be a safe and effective single-dose treatment for hypophosphatasia (HPP).

8 Jun 2021

Harmful DNA mutations play a key role in the conservation of threatened species

Researchers in Lund, Copenhagen, and Norwich have demonstrated that detrimental mutations in DNA play a vital—but often overlooked—role in vulnerable species translocation and conservation initiatives.

8 Jun 2021

Study describes the impact of DNA methylation on the 3D structure of genome

Although all cells in an organism share the same DNA sequence, their shapes, roles, and even lifespans differ drastically.

4 Jun 2021

New process reinvigorates the search for natural drugs to treat cancers

A research team has devised a new method that might revitalize the hunt for natural product medications to treat viral infections, cancer, and other diseases.

4 Jun 2021

Scientists design new gene drive to stop the transmission of devastating diseases

CRISPR-based technologies offer enormous potential to benefit human health and safety, from disease eradication to fortified food supplies. As one example, CRISPR-based gene drives, which are engineered to spread specific traits through targeted populations, are being developed to stop the transmission of devastating diseases such as malaria and dengue fever.

From UC San Diego 3 Jun 2021

Scientists generate first-ever maps of genome's motions before and after cell differentiation

The organization of the human genome relies on physics of different states of matter - such as liquid and solid - a team of scientists has discovered.

3 Jun 2021

Study measures the mass of human chromosomes using X-rays for the first time

In a recent study led by UCL researchers, the mass of human chromosomes was quantified using X-rays for the first time.

From University College London 3 Jun 2021

New method can help diagnose unsolved cases of rare diseases across Europe

Experts in rare diseases have recently described the results of a collaboration to diagnose individuals living with unsolved cases of rare disorders throughout Europe.

3 Jun 2021

New study on genotype-phenotype associations sheds light on human complex traits, diseases

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

2 Jun 2021

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.

2 Jun 2021

Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

Scientists develop new method that enables single-cell RNA sequencing in large number of cells

RNA sequencing is a powerful technology for studying cells and diseases. In particular, single-cell RNA sequencing helps uncover the heterogeneity and diversity of our body.

2 Jun 2021

Biologists use eDNA technique to find invasive snails

Invasive species, beware: Your days of hiding may be ending. Biologists led by the University of Iowa discovered the presence of the invasive New Zealand mud snail by detecting their DNA in waters they were inhabiting incognito.

2 Jun 2021

A gene that impacts the development of bone cancer in children discovered

Researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children.

2 Jun 2021

Each city has its own exclusive microbiome, finds study

A new study performed by researchers report that each city has its own exclusive microbiome or a “fingerprint” of bacteria and viruses that uniquely identify it.

1 Jun 2021

Study examines if myoDN improves myoblast differentiation exacerbated by diabetes

Skeletal muscle makes up 30% to 40% of body weight and serves multiple functions like heat production and energy metabolism.

1 Jun 2021

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Scientists have come up with an innovative function for the metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) in glioblastoma (GBM).

1 Jun 2021

Genetic differences within microalgal symbionts relate to the coral species they inhabit

The microscopic algae that live inside and provide nutrients to their reef-building coral hosts may be evolving in tandem with the corals they inhabit, so each partner is fine-tuned to meet one another's needs.

From Penn State University 1 Jun 2021

New study shows why some children get secondary leukemia after neuroblastoma treatment

Researchers from the Wellcome Sanger Institute and the University of Cambridge discovered that in children with neuroblastoma—a tumor of immature nerve cells—platinum chemotherapy created mutations in the genome that might lead to leukemia in some children later on.

31 May 2021

Genetic editing tools stop the spread of Culex mosquitoes

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue and other life-threatening diseases.

From UC San Diego 31 May 2021

Genomics

Gene therapy may be a safe and effective single-dose treatment for hypophosphatasia

Harmful DNA mutations play a key role in the conservation of threatened species

Study describes the impact of DNA methylation on the 3D structure of genome

New process reinvigorates the search for natural drugs to treat cancers

Scientists design new gene drive to stop the transmission of devastating diseases

Scientists generate first-ever maps of genome's motions before and after cell differentiation

Study measures the mass of human chromosomes using X-rays for the first time

New method can help diagnose unsolved cases of rare diseases across Europe

New study on genotype-phenotype associations sheds light on human complex traits, diseases

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

Scientists develop new method that enables single-cell RNA sequencing in large number of cells

Biologists use eDNA technique to find invasive snails

A gene that impacts the development of bone cancer in children discovered

Each city has its own exclusive microbiome, finds study

Study examines if myoDN improves myoblast differentiation exacerbated by diabetes

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Genetic differences within microalgal symbionts relate to the coral species they inhabit

New study shows why some children get secondary leukemia after neuroblastoma treatment

Genetic editing tools stop the spread of Culex mosquitoes

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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