Genomics

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New research identifies and mitigates bias in CRISPR-Cas9 gene editing

A phenomics approach to study proximity bias and the unrelated chromosomal truncations.

10 Jun 2024

Study Reveals Diversity of DNA Transposons and Expands Genome Engineering Toolbox

In a study published in Cell, a research team led by Zhang Yong'e and WANG Haoyi from the Institute of Zoology of the Chinese Academy of Sciences has characterized the diversity of DNA transposons and expanded the genome engineering toolbox.

7 Jun 2024

Genetic Insights into Salt Gland Formation and Stress Responses in Sea Lavender

Basic helix–loop–helix (bHLH) transcription factors are essential for various plant processes, including growth, development, and stress responses.

7 Jun 2024

Critical NPC Protein Nup358 Linked to Myeloid Disorders

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation.

6 Jun 2024

Genetic Clues Unveil New Insights into Restless Leg Syndrome

Scientists have discovered genetic clues to the cause of restless leg syndrome, a condition common among older adults.

6 Jun 2024

Study Unveils Key Mechanism of Telomere Maintenance by CST–Polα/Primase

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, resulting in telomere disorders with serious health consequences.

6 Jun 2024

GSE3 Gene Editing Paves the Way for Mechanized Hybrid Rice Breeding

In a study published in Nature Plants, Prof. LI Yunhai from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences and Profs. ZHU Xudong and WANG Yuexing from the China National Rice Research Institute have identified an ideal small grain size gene, GSE3.

5 Jun 2024

New Computational Method STew Bridges Gap Between Gene Expression and Spatial Biology

In disease research, it's important to know gene expression and where in a tissue the expression is happening, but marrying the two sets of information can be challenging.

5 Jun 2024

Researchers Advance Single-Molecule DNA Sequencing Techniques

In recent years, technologies that allow scientists to investigate a person's DNA at single-molecule resolution have greatly increased the knowledge of the human genome, microbiome, and the genetic basis of disease.

5 Jun 2024

Impact of Rare Disease Mutation Could Extend to More Prevalent Conditions

REX1 is a gene that is meant to direct the maintenance of the entire body’s DNA, but new research shows that when people are born with mutated TREX1, the DNA suffers catastrophic damage over time, resulting in a deadly rare disease known as retinal vasculopathy with cerebral leukoencephalopathy (RVCL).

5 Jun 2024

CRISPR/Cas Biosensors Address Sensitivity and Specificity Challenges in Detection

The mechanisms of CRISPR-Cas-based biosensors.

5 Jun 2024

Ferns and Ants Forge Mutualistic Relationships Through Evolutionary Innovations

Collaborations across research disciplines can lead to unexpected breakthroughs and discoveries. Collaborations across species lead to unexpected evolutionary paths of mutual benefit.

4 Jun 2024

Graph Neural Networks: A Novel Approach to Deciphering Gene-Enhancer Interactions

Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity.

4 Jun 2024

Protein SRSF1 Plays Unexpected Role in Unwinding Complex RNA Structures

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

31 May 2024

New Birnavirus Discovered in Pet Trade Zebrafish

Zebrafish in the pet trade are asymptomatic carriers of previously undescribed microbes, including a novel virus that causes hemorrhaging in infected laboratory fish, Marlen Rice from the University of Utah, US, and colleagues report in the open-access journal PLOS Biology, publishing May 23rd.

31 May 2024