Genomics

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New AI Model Predicts Protein-DNA Binding Specificity with High Accuracy

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments.

12 Aug 2024

Utah Scientists Begin New Project to Map Epigenetic Changes Across the Human Genome

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved.

12 Aug 2024

Bacterial Defense Mechanism Revealed Through RNA-Derived Gene Synthesis

Researchers have uncovered a surprising way bacteria defend themselves: when a bacterium is infected, bacterial enzymes that copy genetic information from RNA into DNA synthesize genes whose protein products help shut down cell growth.

12 Aug 2024

Discovery of Largest Protein Sheds Light on Toxin Production in Marine Algae

While seeking to unravel how marine algae create their chemically complex toxins, scientists at UC San Diego's Scripps Institution of Oceanography have discovered the largest protein yet identified in biology.

12 Aug 2024

Peers' Genetic Traits Impact Long-Term Risk for Substance Use and Psychiatric Disorders

Mom always said, "Choose your friends wisely." Now a study led by a Rutgers Health professor shows she was onto something: Their traits can rub off on you – especially ones that are in their genes.

12 Aug 2024

Exploring Retrotransposon-Derived DNA Zip Codes in Myeloma Cell Internalization

A new editorial was published in Oncoscience (Volume 11) on July 13, 2024, entitled, "Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization."

12 Aug 2024

Discovery of Free-Floating Genes in Bacteria Challenges Genetic Code Assumptions

Since the genetic code was first deciphered in the 1960s, our genes seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why changes in a gene's code affect health.

12 Aug 2024

Scientists Develop AI-Powered Tool to Optimize Gene Delivery

Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.

9 Aug 2024

New Findings Shed Light on ATM Activation in DNA Repair

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

9 Aug 2024

Scientists Create Disease-Resistant Potatoes Using CRISPR

The global food system is under increasing pressure due to the compounding effects of climate change, which exacerbates the prevalence of pests and diseases in crops. Potatoes, being the third most important food crop worldwide, are particularly at risk. The quest for sustainable agricultural practices necessitates the development of crops that can withstand these adversities, prompting an urgent need for research into enhancing the inherent resilience of our staple foods.

9 Aug 2024

Gene Editing Creates Prickle-Free Eggplants for Easier Farming

Eggplants, a staple crop globally, present significant challenges in cultivation and harvesting due to their prickles. These prickles, which serve as a natural defense mechanism, complicate handling and reduce efficiency in agricultural practices. Addressing these issues is crucial for improving farming outcomes. Consequently, researchers are focused on understanding the genetic basis of prickle formation to develop prickle-free eggplant varieties. Based on these challenges, there is a pressing need to conduct in-depth research and identify solutions for more efficient eggplant cultivation.

9 Aug 2024

Noninvasive Ultrasound Method Enables Tracking of Gene Expression in Specific Brain Regions

The ability to alter or prevent the expression of faulty genes in the brain could be leveraged as a powerful therapeutic against neurodegenerative disease. However, the molecular underpinnings of the living brain are still largely inaccessible, hampering progress on such promising therapeutics.

9 Aug 2024

LINE-1 RNA from Ancient Viruses Promotes Bone Repair

Around half of the human genome is composed of DNA fragments originating from ancient viruses. These "transposable elements" (TEs) are now known to play various roles in modulating gene expression and disease development.

8 Aug 2024

Advancements in Grape Genomics Promise Enhanced Breeding Strategies

Grapes are economically and culturally significant worldwide, but climate change has posed substantial challenges to grape production in recent decades.

8 Aug 2024

Researchers Uncover Method to Boost Stem Cell Production Using Interferon Gamma

Researchers at the Centre for Genomic Regulation (CRG) have discovered a treatment which accelerates the production and quality of pluripotent stem cells in mice.

8 Aug 2024

Detailed Analysis of Cucumber Centromeres Uncovers Key DNA Sequences and Retrotransposons

Centromeres are crucial for chromosome segregation during cell division and consist of repetitive DNA sequences.

8 Aug 2024

Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

8 Aug 2024

Study Reveals 70 Million Years of Host-Parasite Genetic Arms Race

Hosts and their parasites are in constant competition. Through genetic diversity, the host can change in such a way that infection is no longer possible.

8 Aug 2024

Genetic Analysis of Potato and Phytophthora infestans During and After the Irish Potato Famine

In an examination of the genetic material found in historic potato leaves, North Carolina State University researchers reveal more about the tit-for-tat evolutionary changes occurring in both potato plants and the pathogen that caused the 1840s Irish potato famine.

6 Aug 2024

Shared Mechanisms in Human and Yeast DNA Replication Revealed

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Sciences.

5 Aug 2024

Genomics

New AI Model Predicts Protein-DNA Binding Specificity with High Accuracy

Utah Scientists Begin New Project to Map Epigenetic Changes Across the Human Genome

Bacterial Defense Mechanism Revealed Through RNA-Derived Gene Synthesis

Discovery of Largest Protein Sheds Light on Toxin Production in Marine Algae

Peers' Genetic Traits Impact Long-Term Risk for Substance Use and Psychiatric Disorders

Exploring Retrotransposon-Derived DNA Zip Codes in Myeloma Cell Internalization

Discovery of Free-Floating Genes in Bacteria Challenges Genetic Code Assumptions

Scientists Develop AI-Powered Tool to Optimize Gene Delivery

New Findings Shed Light on ATM Activation in DNA Repair

Scientists Create Disease-Resistant Potatoes Using CRISPR

Gene Editing Creates Prickle-Free Eggplants for Easier Farming

Noninvasive Ultrasound Method Enables Tracking of Gene Expression in Specific Brain Regions

LINE-1 RNA from Ancient Viruses Promotes Bone Repair

Advancements in Grape Genomics Promise Enhanced Breeding Strategies

Researchers Uncover Method to Boost Stem Cell Production Using Interferon Gamma

Detailed Analysis of Cucumber Centromeres Uncovers Key DNA Sequences and Retrotransposons

Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

Study Reveals 70 Million Years of Host-Parasite Genetic Arms Race

Genetic Analysis of Potato and Phytophthora infestans During and After the Irish Potato Famine

Shared Mechanisms in Human and Yeast DNA Replication Revealed

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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