Genomics

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Megamonas Bacteria Identified as Potential Obesity Culprit

A recent study from Cell Host & Microbe identifies Megamonas as a possible bacteria linked to obesity based on a large-scale cohort of obese Chinese people. This study demonstrates how the bacterium increases lipid absorption, breaks down intestinal myo-inositol, and causes obesity, which may lead to future approaches for managing obesity.

5 Aug 2024

Breakthrough Method Captures Aging Impact on Alzheimer’s Disease in Lab-Grown Neurons

Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer's disease.

2 Aug 2024

Innovative Nanosensing Method Promises Safer Gene Therapy with Improved AAV Vector Quality

Over the past few decades, there has been remarkable progress in genetic manipulation technologies, bringing us closer to the point where genes can be modified in vivo.

2 Aug 2024

Revealing the Spatial Dynamics of Sebum Production

Changes in gene expression in sebaceous glands have been spatially mapped for the first time in a collaborative project between Leipzig University's Interdisciplinary Centre for Bioinformatics (IZBI) and the Faculty of Veterinary Medicine.

1 Aug 2024

Exploring the Hidden Costs of Industry-Funded Genetic Testing

According to authors writing in a commentary for the Canadian Medical Association Journal, free genetic testing that is either fully or partially funded by business may have trade-offs.

30 Jul 2024

Transposable Elements Influence Genome Size and Gene Expression in Rosaceae Plants

Transposable elements are mobile DNA sequences that play a crucial role in plant genome architecture and gene regulation.

30 Jul 2024

New Study Uncovers Genetic Secrets of Cotton's Drought Resilience

Cotton is woven into the very fabric of our lives, from soft T-shirts to comfortable jeans and cozy bedsheets.

30 Jul 2024

Study Reveals Widespread Gene Misbehavior in Healthy Humans

Scientists have uncovered that ‘gene misbehaviour’ – where genes are active when they were expected to be switched off – is a surprisingly common phenomenon in the healthy human population.

29 Jul 2024

Researchers Discover Link Between Neolithic Farming and Brucellosis

Scientists believe the bacterial infection brucellosis, which affects millions of people every year and causes significant harm to the welfare of livestock, may have evolved along with the development of farming. They came to this conclusion after performing analyses of ancient DNA extracted from an 8,000-year-old sheep bone, in which the Brucella melitensis pathogen was detected.

29 Jul 2024

Effective Plasmid DNA Delivery Achieved with Zwitterionic Polymer Complex

Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins. The new compound effectively bound to plasmid DNA without affecting its structure. Injected into mouse muscles, the team observed widespread gene expression, promising applications to treatments of serious muscle diseases.

29 Jul 2024

Specific Genes May Determine Stroke Recovery Path

New research led by UCLA Health has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing doctors insights useful for developing targeted therapies.

29 Jul 2024

New Gene Therapy Approach Improves Muscle Strength in DMD Mice

Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments for people with Duchenne muscular dystrophy (DMD).

29 Jul 2024

Plant-Based Diet Slows Down Biological Aging Markers

Eating a vegan diet for eight weeks is associated with reductions in biological age estimations based on levels of DNA methylation -; a type of chemical modification of DNA (known as an epigenetic modification) that alters gene expression but not DNA itself. Previous research has reported that increased DNA methylation levels are associated with aging. The findings, which are based on a small randomized controlled trial of 21 pairs of adult identical twins, are published in BMC Medicine.

29 Jul 2024

Unraveling the Complexities of X Chromosome Inheritance

A new study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences has reveals that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body.

26 Jul 2024

Advancing Cancer Drug Discovery: The Enduring Value of Phenotypic Screening

The niche areas in which phenotypic screening continues to be advantageous over the targeted approach, and the recent advances in phenotypic screening technology that have increased their efficiency.

26 Jul 2024

Cost-Effective Array Sheds Light on Imprinted Gene Regulation

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array represents a cost-effective, efficient method for exploring potential links between environmental exposures and epigenetic dysregulation during the early developmental origins of diseases and behavioral disorders.

26 Jul 2024