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Metal labeling strategy for single-cell multiplexing with mass cytometry

Recently, a new metal labeling strategy has been suggested by researchers from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences (CAS) to boost mass cytometry’s sensitivity and increase the number of MC detection channels.

31 Mar 2023

Personal genome sequencing and personalized medicine

Genetic mutations have given life on Earth a stunning variety of various sizes, colors, and shapes. Some changes are beneficial, while others are dangerous or ineffective. There are about 4.5 million genetic variants per individual.

31 Mar 2023

Revealing the structural basis underpinning the biophysical properties of pili

According to the World Health Organization, enterotoxigenic Escherichia coli (ETEC) bacteria are the most common cause of traveler’s diarrhea and cause the greatest number of known community-acquired cases of childhood diarrhea in the developing world.

31 Mar 2023

Gene variants that improve nitrogen utilization identified

Nitrogen as a fertilizer can boost yields. Too much nitrogen, on the other hand, can have negative consequences such as high energy consumption in fertilizer manufacturing.

31 Mar 2023

Maternal vaginal microbiome does not substantially influence the infant stool microbiome

It has been a longstanding assumption that birth mode and associated exposure of newborns to their mothers' vaginal microbiome during delivery greatly affects the development of babies' gut microbiome.

31 Mar 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Previously unknown telomere and cancer connection to the immune system revealed

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.

31 Mar 2023

Immune cells in human blood produce acetylcholine that regulates blood pressure and inflammation

Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear. Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation.

31 Mar 2023

Clearance of senescent cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

31 Mar 2023

Neutrophils can affect the success of immunotherapy in treating cancer, study shows

Cancer immunotherapies that recruit a patient's own immune system to destroy tumors have transformed the treatment of many types of cancer. Yet these therapies do not elicit universally good treatment responses.

31 Mar 2023

BGI Genomics and Zentya collaborate to launch COLOTECT in Slovakia

BGI Genomics is pleased to announce the launch of COLOTECTTM 1.0 in Slovakia, in collaboration with its local partner, Zentya. Zentya is a Slovak-based healthcare solution provider that is passionate about providing patients with the latest technology in the field of genetic screening, aiming to help identify and facilitate timely treatments of genetic diseases.

31 Mar 2023

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

A new study conducted at the National Eye Institute (NEI) has identified incredibly rare genetic variants that might uncover the mechanisms underlying the development of AMD.

31 Mar 2023

Harnessing a natural bacterial system to deliver proteins in mice and human cells

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals.

30 Mar 2023

Research shows how the fruit fly gut builds a cozy niche to selectively promote colonization

The digestive tract of fruit flies remodels itself to accommodate beneficial microbiome species and maintain long-term stability of the gut environment, according to new research led by Carnegie's William Ludington and Allan Spradling.

30 Mar 2023

Six compounds contribute to the fermented coffee experience, scientists report

Specialty coffees are gaining traction in coffeehouses around the world -; and now a fermented version could bring a fruity taste to your morning cup of joe.

30 Mar 2023

Study helps understand at the cellular level how physical activity contributes to fitness during aging

Regular exercise can guarantee quality of life and longevity, specialists agree. However, exactly how exercise influences the functioning of muscle cells is poorly understood.

30 Mar 2023

Ancient DNA reveals African founders intermingled with southwest Asian people around 1000 CE

While serfs toiled and knights jousted in Europe and samurai and shoguns rose to power in Japan, the medieval peoples of the Swahili civilization on the coast of East Africa lived in multicultural, coral-stone towns and engaged in trade networks spanning the Indian Ocean.

30 Mar 2023

Single monoclonal antibody infusion can strengthen the body's fight against yellow fever

New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment.

30 Mar 2023

COVID-19 vaccines boost the levels of T cells in immunocompromised hematology patients

Researchers found that, despite being heavily immunocompromised, hematology patients generate strong cellular immune responses against SARS-CoV-2 after vaccination, on par with that of healthy individuals.

30 Mar 2023

FDA-approved compound promotes photoreceptor survival in lab models of inherited retinal ciliopathy

A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

30 Mar 2023

Life Science News

Metal labeling strategy for single-cell multiplexing with mass cytometry

Personal genome sequencing and personalized medicine

Revealing the structural basis underpinning the biophysical properties of pili

Gene variants that improve nitrogen utilization identified

Maternal vaginal microbiome does not substantially influence the infant stool microbiome

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Previously unknown telomere and cancer connection to the immune system revealed

Immune cells in human blood produce acetylcholine that regulates blood pressure and inflammation

Clearance of senescent cells by boosting anti-viral immune response

Neutrophils can affect the success of immunotherapy in treating cancer, study shows

BGI Genomics and Zentya collaborate to launch COLOTECT in Slovakia

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

Harnessing a natural bacterial system to deliver proteins in mice and human cells

Research shows how the fruit fly gut builds a cozy niche to selectively promote colonization

Six compounds contribute to the fermented coffee experience, scientists report

Study helps understand at the cellular level how physical activity contributes to fitness during aging

Ancient DNA reveals African founders intermingled with southwest Asian people around 1000 CE

Single monoclonal antibody infusion can strengthen the body's fight against yellow fever

COVID-19 vaccines boost the levels of T cells in immunocompromised hematology patients

FDA-approved compound promotes photoreceptor survival in lab models of inherited retinal ciliopathy

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