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Researchers Develop Highly Selective SARS-CoV-2 Mpro Inhibitors

New research from The Wistar Institute's Salvino lab -; led by professor Joseph Salvino, Ph.D. -; has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.

9 Oct 2024

New RNA Molecule Found to Boost Wound Healing

A new study from Karolinska Institutet in Sweden and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing. The research, published in Nature Communications, may have implications for the treatment of hard-to-heal wounds.

9 Oct 2024

Bird Migration and Invasive Species Fuel Parasite Spread

A single shift of a parasite from one host species to another can trigger catastrophic infectious disease outbreaks. Despite this, scientists continue to debate the role of species diversity in natural environments on the spread of these parasites.

9 Oct 2024

Engineering Tissue Domains with a Synthetic Biology Approach

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, demonstrate how morphogens combined with cell adhesion can generate tissue domains with a sharp boundary in an in vitro model system.

9 Oct 2024

Study Unravels the Mystery of Hsp70 Chaperones

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality.

9 Oct 2024

Scientists Map the Entire Brain of a Fruit Fly

UC Santa Barbara neuroscientists have reconstructed the entire anterior visual pathway of a fruit fly, a complex series of connections between the insect's eyes and the navigation center of its brain. With the help of artificial intelligence and manual proofreading, systems biologist Sung Soo Kim's research group and collaborators worked out the relationships between more than 3,000 neurons with unprecedented detail.

9 Oct 2024

Unveiling the Enzymatic Riches of Spider Venoms

Spiders, as venomous creatures, employ their chemical arsenal for prey acquisition or self-defense. Their venom contains small neurotoxins that target the central nervous system of their targets.

8 Oct 2024

Bioengineered Bacteria with Mussel-Like Adhesion Could Clean Up Plastic

Researchers at Rice University have created bioengineered microbes with strong adhesion that have the potential to revolutionize environmental cleanup by drawing on nature's genius for adhesives, the sticky power of mussels.

8 Oct 2024

CAR-NKT Cells Show Promise in Overcoming Solid Tumor Barriers

Chimeric antigen receptor T-cell therapy (CAR-T) has shown significant promise in the treatment of blood malignancies in the fight against cancer.

8 Oct 2024

New Approach Aims to Enhance CRISPR Safety and Precision

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism.

8 Oct 2024

UNC Researchers Unveil CAR-NKT Therapy for Enhanced Antitumor Activity

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.

8 Oct 2024

Scientists Uncover Secrets of Circadian Rhythm Control

Scientists from Duke-NUS Medical School and the University of California, Santa Cruz, have discovered the secret to regulating our internal clock.

8 Oct 2024

Transforming Microbiome Research with Single-Cell Genome Analysis

The human microbiome plays a critical role in our health, influencing everything from disease development to treatment responses.

8 Oct 2024

How Comamonas Bacteria Transform Plastic Waste into Food

Researchers have long observed that a common family of environmental bacteria, Comamonadacae, grow on plastics littered throughout urban rivers and wastewater systems.

7 Oct 2024

The Promise of Venomous Crustaceans in Drug Development

Many animals use venoms for self-defense or hunting. The components of such venom, known as toxins, interfere with various physiological processes - which is also the reason why they are so interesting for the development of new pharmacological agents.

7 Oct 2024

Uncovering Hidden Bacteria in Antibiotic Resistance

Imagine a country with a billion people, where every individual has different interests and different goals. You will never know their interests and goals until you ask them, but asking a billion people is not an easy task.

7 Oct 2024

Uncovering the Genetic Drivers of Metastatic Prostate Cancer

Researchers at the University of Michigan Rogel Cancer Center have recently uncovered a novel subtype of aggressive prostate cancer.

7 Oct 2024

Novel Phage Cocktail Combats Antibiotic-Resistant Infections

A novel strategy has been developed by researchers to combat drug-resistant bacterial infections.

7 Oct 2024

New Approaches to Treating Circadian Rhythm Disorders

Researchers from the University of California and Duke-NUS Medical School have figured out how to control the human body's internal clock. It was discovered that this regulator is located exactly at the end of Casein Kinase 1 delta (CK1δ), a protein that sets the pace for circadian rhythm, or internal biological clock, which regulates sleep-wake cycles and other daily activities.

7 Oct 2024

Fighting Drug-Resistant TB with a Novel Antibiotic

A novel semi-synthetic molecule that produces significant activity against strains of Mycobacterium tuberculosis, including those that are resistant to drugs, can be generated from natural compounds according to a study published in the American Society for Microbiology journal Microbiology Spectrum.

4 Oct 2024