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Human Stem Cell-Derived Retinal Organoid Sheets Close Macular Holes

Researchers reported in the journal Stem Cell Reports that retinal holes in a monkey model were successfully healed by transplanting human stem cells. Following transplantation, retinal tissue was continuously added to the macular holes to seal them.

4 Oct 2024

Harnessing Bioluminescence for Noninvasive Brain Activation

Researchers at the University of Rochester have demonstrated a noninvasive technique called bioluminescent optogenetics, or BL-OG, that uses light to stimulate brain neurons.

4 Oct 2024

Owlstone Medical and FDA Join Forces for Volatile Organic Compound Identification

Owlstone Medical (“Owlstone”), the global leader in Breath Biopsy® for applications in early disease detection and precision medicine, today announced it has entered into a Research Collaboration Agreement with the FDA’s Center for Devices and Radiological Health (“CDRH”) - Office of Science and Engineering Laboratories (OSEL).

4 Oct 2024

"Paralog Hopping" Uncovers New Binding Sites for Cancer Drugs

Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites.

4 Oct 2024

New Quantum Algorithm Could Drastically Speed Up Drug Discovery

University of Copenhagen mathematicians have developed a recipe for upgrading quantum computers to simulate complex quantum systems, such as molecules. Their discovery brings us closer to being able to predict how new drugs will behave within our bodies and has the potential to revolutionize pharmaceutical development.

4 Oct 2024

Innovative Mouse Models Shed Light on SARS-CoV-2 Infection Mechanisms

Scientists at La Jolla Institute for Immunology (LJI) have developed six lines of humanized mice that can serve as valuable models for studying human cases of COVID-19.

4 Oct 2024

Zinc Inhibits Plasmid Transfer in Gut Microbes

Genes responsible for antimicrobial resistance (AMR) can spread from microbe to microbe through circular genetic material called plasmids, and this lateral transfer occurs in the gut. This week in Applied and Environmental Microbiology, researchers in Iowa report that the transmission of some AMR plasmids may be inhibited by a readily available source-;dietary zinc supplements.

4 Oct 2024

Microbial Enzyme From Sewage Sludge Offers Hope for Plastic Waste Reduction

Plastic pollution is everywhere, and a good amount of it is composed of polyethylene terephthalate. This polymer is used to make bottles, containers and even clothing.

4 Oct 2024

Living Microbes Unearthed in 2-Billion-Year-Old Rock

Pockets of microbes have been found living within a sealed fracture in 2-billion-year-old rock. The rock was excavated from the Bushveld Igneous Complex in South Africa, an area known for its rich ore deposits. This is the oldest example of living microbes being found within ancient rock so far discovered.

4 Oct 2024

EPA-Funds Study on Antimicrobial Resistance in Wastewater and Agricultural Runoff

Aided by a $2.4 million grant from the Environmental Protection Agency, a team of University of Nebraska–Lincoln engineers and scientists is leading a multi-state effort to assess the potential threat to human health from antimicrobial-resistant pathogens spread via wastewater and agricultural runoff.

4 Oct 2024

Genes2Genes Unlocks New Potential for Detecting Gene Expression Changes

Genes2Genes an accurately infer alignments in simulated and real datasets of single-cell trajectories and capture sequential mismatches and matches in individual genes.

4 Oct 2024

Mapping the Complex Structure and Function of CRISPR-Cas Protein Scissors

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions.

3 Oct 2024

Scientists Successfully Map the Entire Fruit Fly Brain

A team of scientists supported by the National Institutes of Health (NIH)'s The BRAIN Initiative, including Davi Bock, Ph.D., Associate Professor of Neurological Sciences at UVM's Robert Larner, M.D. College of Medicine, recently made a substantial advancement in neurobiological research by successfully mapping the entire brain of Drosophila melanogaster, more commonly known as the fruit fly.

3 Oct 2024

Discovering New Drug Targets Through Paralog Hopping

3 Oct 2024

Structural Discovery of Fanzor Proteins Offers New Directions in Genome Engineering

A revolution in biomedicine is currently underway, driven by the application of genome engineering tools such as the prokaryotic CRISPR-Cas9.

3 Oct 2024

New Insights into the Epigenetic Hallmarks of Cancer

Cancer mortality has just surpassed cardiovascular disease for the first time ever and one in two men, and one in three women, will be diagnosed with some form of the disease in the US, according to the NIH.

3 Oct 2024

Unlocking the Mysteries of Repeat Expansion in Genetics

Research led by scientists at Queen Mary University of London is heralding in a new era for genetic sequencing and testing.

3 Oct 2024

A New Understanding of Chromatin Regulation and its Implications

Human survival is dependent upon an extraordinarily intricate dance that takes place inside every cell and every nucleus. DNA is continually being wrapped and unwrapped by proteins, and even small mistakes might result in cancer.

3 Oct 2024

Unraveling the Mysteries of Endosymbiotic Relationships

Endosymbiosis refers to a remarkable biological process where one organism resides within another. This unique arrangement is frequently advantageous for both organisms involved.

3 Oct 2024

Tuft Cells: A New Hope for Gut Healing

Immunological cues cause intestinal tuft cells to proliferate and create new cells. Furthermore, tuft cells can withstand severe damage, such as radiation damage, and aid in the regeneration of the epithelium, in contrast to progenitor- and stem cells.

3 Oct 2024