Drug Discovery News and Research

RSS

The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio Innovations Limited 26 Apr 2022

Cryo-EM reveals the structure of fermentation enzyme phosphoketolase

Pharmaceuticals, plastics, and other industries use enzymes to help synthesize molecular feedstocks.

19 Apr 2022

Scientists discover a special cell in salivary glands that is likely crucial for oral health

Scientists at Scripps Research and the National Institute of Dental and Craniofacial Research have discovered a special type of cell that resides in salivary glands and is likely crucial for oral health.

13 Apr 2022

Venomtech announces new drug development collaboration with Charles River

Venomtech is collaborating with Charles River Laboratories, International Inc. to help drug developers explore venom-derived compounds for a wide range of therapeutic targets.

12 Apr 2022

Arrayjet introduces Mercury range of next-generation microarray printers

Arrayjet, a leading provider of inkjet liquid-handling solutions, today introduced Mercury, a new core range of five instruments for ultra-low-volume liquid dispensing.

From Arrayjet Ltd 4 Apr 2022

Research reveals how a building block protein assembles to form poxvirus scaffold

Researchers at the Okinawa Institute of Science and Technology Graduate University have revealed how poxviruses build their scaffold - a temporary protein coat that forms and disappears as the virus matures.

1 Apr 2022

How Important are Data Clouds to Life Sciences Research?

In this interview, we speak to Mike Tarselli, CSO of TetraScience, about their Tetra data cloud and the role it plays within scientific data analysis.

From TetraScience, Inc. 31 Mar 2022

AI and robotics identify new cellular hallmarks of Parkinson's disease

A study published today in Nature Communications unveils a new platform for discovering cellular signatures of disease that integrates robotic systems for studying patient cells with artificial intelligence methods for image analysis.

28 Mar 2022

Researchers analyze a powerful tool to enhance drug discovery

Hormones or chemical messengers link to cell membrane receptors to tweak how the cell responds, creating a metaphorical interaction and traffic network on the surface of cell membranes inside human body.

23 Mar 2022

Researchers create a mobile app to calculate genetic risk for coronary artery disease

A Scripps Research team developed a smartphone app that can calculate users' genetic risk for coronary artery disease (CAD)-; and found that users at high risk sought out appropriate medication after using the app.

15 Mar 2022

Researchers show how hotspot maps can detect structures contributing to compounds’ selectivity

The quantity of structural data available on protein drug targets keeps growing.

4 Mar 2022

Future of AI in Life Science Research

In partnership with the SLAS 2022 exhibition and conference, we speak to Brian O’Sullivan about artificial intelligence and its future within the life sciences sector.

From Society for Laboratory Automation and Screening (SLAS) 1 Mar 2022

New study uncovers potential driver of Parkinson’s disease

Parkinson's disease may be driven in part by cell stress-related biochemical events that disrupt a key cellular cleanup system, leading to the spread of harmful protein aggregates in the brain, according to a new study from scientists at Scripps Research.

24 Feb 2022

Semarion raises £2.14 million GBP ($2.89 million USD) seed funding

Semarion Ltd, a University of Cambridge spin-out company from the Cavendish Laboratory combining materials engineering and cell biology to tackle unmet drug screening needs, announced today that it has closed a £2.14 million GBP seed funding round.

22 Feb 2022

Automata raises US $50 million in series B financing to accelerate automation in life science

Automata – the automation company helping life sciences rapidly innovate, diagnose and discover at scale – today announces it has raised US$50 million in Series B funding.

From Automata Technologies 22 Feb 2022

3D structure of protein channel helps shed light on sensitive touch response of Venus fly traps

Scientists at Scripps Research have revealed the three-dimensional structure of Flycatcher1, an aptly named protein channel that may enable Venus fly trap plants to snap shut in response to prey.

18 Feb 2022

NTU Singapore scientists design new method to generate sulfur pharmacophores

A key technical challenge in creating new sulfur-based medicines has been overcome by scientists at Nanyang Technological University, Singapore, leading to the prospect of many new therapeutic 'weapons' in the fight against disease and illness.

15 Feb 2022

Researchers design a molecule that prevents the replication of coronaviruses

Researchers have created a molecule that suppresses coronavirus replication and has the potential to be developed into a COVID-19 treatment drug.

14 Feb 2022

Agricultural fungicides generate resistance to antifungal medications, study finds

For the first time, a new study has revealed that drugs, used to treat fungal illnesses in plants, are also generating resistance to antifungal medications used to treat people.

From University of Georgia 14 Feb 2022

A simple route for synthesizing fungal compound and its derivatives

The solutions to many of humanity's problems can be found within nature. For instance, who could have guessed that an antibiotic as powerful as penicillin would be found in a common mold, or that the drug aspirin would be derived from the bark of the willow tree?

From Tokyo University of Science 10 Feb 2022