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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Using CRISPR technology to reduce the symptoms of Huntington’s disease

A neurological condition called Huntington's disease (HD) results in a progressive decline in movement, coordination, and mental ability. It is brought on by a mutation in the huntingtin, or HTT, gene.

From UC San Diego 14 Dec 2022

'Harmless' species of Listeria developing characteristics potentially harmful to humans

In the food processing industry, the deadly bacteria Listeria monocytogenes is monitored closely. Not only can the bacteria make people extremely ill, it is known to be developing resistance to various food safety measures across the world.

6 Dec 2022

New 3D organoid model reveals a possible biological target for treating GEJ cancers

Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction (GEJ) — the point where the digestive system's food tube meets the stomach.

2 Dec 2022

Study unravels a novel function of the gene scissors

Many years earlier, the CRISPR/Cas9 gene scissors have been making a sensation in science and medicine. This new tool of molecular biology consists of its origins in an ancient bacterial immune system.

28 Nov 2022

Gaining better insights into the origins of jaws by DNA sequence

At Uppsala University, a DNA sequence found in jawed vertebrates has been discovered and characterized by scientists. This includes sharks and humans, but it is absent in jawless vertebrates, like lampreys.

28 Nov 2022

Newly developed tool helps snip out faulty genes in a safe manner

Scientists from the Massachusetts Institute of Technology (MIT) have come up with a new tool that has the potential to detach faulty genes and exchange them with new ones in a highly safe and effective way.

From Massachusetts Institute of Technology (MIT) 25 Nov 2022

Highlighting the potential of new techniques to study mental disorders

Researchers investigating the fundamental brain mechanics of autism spectrum disorder have discovered that a gene mutation known to be connected with the illness causes considerably more overstimulation of brain cells than in neuronal cells without the mutation.

23 Nov 2022

Expanding the CRISPR-based toolbox for extensive genome engineering

Researchers from North Carolina State University describe a variety of CRISPR-Cas systems-based molecular tools to rewrite, rather than just edit, significant portions of an organism’s DNA.

23 Nov 2022

Study offers insight into the working and importance of Fd/Trx pathway in plants

Photosynthesis is one of the most important chemical reactions, not just for plants but also for the entire world.

22 Nov 2022

CRISPR technology to improve the efficacy of immunotherapy

Using CRISPR technology for the first time, researchers have inserted genes that enable immune cells to concentrate their attack on cancer cells, potentially sparing healthy cells and boosting the effectiveness of immunotherapy.

14 Nov 2022

Treatment using CRISPR alleviates swelling attacks in hereditary angioedema patients

Hereditary angioedema (HAE) is a rare, genetic disorder characterized by severe, recurring, and unpredictable swelling attacks in various organs and tissues of the body, which can be painful, debilitating, and life-threatening.

11 Nov 2022

Researchers unravel the role of plant hormones in preventing Striga infestations

As part of a multipronged approach to prevent infestations by the parasitic plant Striga hermonthica, researchers are unraveling the role of plant hormones, known as strigolactones (SLs).

3 Nov 2022

Low protein synthesis in humans causes rare intestinal disease

According to a recent study, which will be published on November 1st, 2022, by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues, a decrease in protein synthesis in growing gut cells contributes to a rare genetic condition, and an affordable nutritional supplement could help reverse that decrease.

3 Nov 2022

New technique could help fine-tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

2 Nov 2022

Potential therapeutic strategy for medulloblastoma relapse

Medulloblastoma, a kind of malignant brain tumor, can develop resistance to therapy, resulting in relapse. Uppsala University scientists found a protein that causes tumor cells to rest and become insensitive to radiation treatment.

1 Nov 2022

Understanding the architectures of proteins and the machinery at genes

Researchers from Cornell University have discovered a crucial mechanism in how genes are controlled thanks to yeast, a small organism that is necessary for the production of beer and bread.

1 Nov 2022

Pioneering gene editing approach could lead to new treatments for CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

From University College London 27 Oct 2022

Genome Editing Has A New Code

In this interview, we speak to Samantha Maragh, the leader of the genome editing program at NIST, about the genome editing vocabulary and what this means for researchers worldwide.

From National Institute of Standards and Technology (NIST) 21 Oct 2022

Broadening the scope of CRISPR-Cas9 genome editing systems

A group of Northwestern University researchers has created a novel gene editing platform that might influence the future application of a nearly infinite library of CRISPR-based therapeutics.

7 Oct 2022

Genomic research helps in tackling the fatal complications of fungal infections

An important genetic discovery made by a research team led by a University of Massachusetts Amherst scientist sheds new light on the application of the drug caspofungin to treat the deadly fungal infection Aspergillus fumigatus, which claims the lives of about 100,000 severely immunocompromised individuals every year.