Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

Early Detection of Off-Target Binding Could Improve Drug Safety

Integral Molecular, a pioneer in antibody discovery and characterization, has published new findings in the journal mAbs, revealing that up to one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

One-Third of Antibody Drugs Show Unintended Target Binding

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Monoclonal Antibody SC27 Shows Broad Effectiveness Against SARS-CoV-2 Variants

A monoclonal antibody appears effective at neutralizing the numerous variants of SARS-CoV-2, as well as related viruses in animals that could pose a threat if they were to begin spreading in people.

10 Sep 2024

LSTM Research Identifies 91 RNA Viruses in Parasitic Worms

New research shows that parasitic nematodes, responsible for infecting more than a billion people globally, carry viruses that may solve the puzzle of why some cause serious diseases.

5 Sep 2024

Atypical B Cells Play a Central Role in COVID-19 Vaccine Response

Vaccines function by strengthening defenses against viruses that invade human bodies. Vaccination against COVID-19 teaches the human immune system's specialized B cells how to identify the virus.

5 Sep 2024

RYBREVANT Receives EC Nod for Advanced Lung Cancer Treatment

Janssen-Cilag International NV, a Johnson & Johnson company, today announced that the European Commission (EC) has approved a Type II extension of indication for RYBREVANT®▼ (amivantamab) in combination with chemotherapy (carboplatin and pemetrexed), for the treatment of adults with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) Exon 19 deletions (ex19del) or Exon 21 L858R substitution (L858R) mutations, after failure of prior therapy including an EGFR tyrosine kinase inhibitor (TKI).

30 Aug 2024

A Landmark Study Reveals the Widespread Existence of DNA i-Motifs

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

30 Aug 2024

New Human Intestinal Immuno-Organoids Reveal Insights into Immune Cell Dynamics and Cancer Immunotherapy

Research on intestinal immuno-organoids reveals their potential in modeling immune interactions and studying intestinal diseases linked to cancer therapies.

26 Aug 2024

The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled "Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation". This review comprehensively summarizes the mechanisms involved in the generation of antigen-specific diversified antibodies, with a particular focus on the mechanisms that generate high-frequency point mutations and low-frequency deletions and insertions (indels) in antibody genes.

22 Aug 2024

Light-Activated Macrophages Show Increased Appetite for Cancer Cells

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer.

13 Aug 2024

Study Challenges Current Understanding of Parkinson's and Lewy Body Disease Onset

Early detection of Alzheimer's disease-related changes in Parkinson's disease and dementia with Lewy bodies could be made possible by monitoring the amyloid-β (Aβ) and phosphorylated tau (p-tau) proteins.

1 Aug 2024

Swabbing Technique Reveals Diversity of Immune Cells in the Upper Airway

Scientists at La Jolla Institute for Immunology (LJI) have published the first-ever, in-depth analysis of immune cell memory in the upper airways of adult volunteers. Among these immune cells, the researcher spotted "tissue resident" memory cells, which stand ready to defend the airway from SARS-CoV-2 and other respiratory diseases.

1 Aug 2024

Antisense Therapy Shows Promise Against Parkinson's

Parkinson's disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies and Lewy neurites depending on their subcellular localization, can spread by continuously causing normal endogenous aSyn to misfold.

26 Jul 2024

UNC Charlotte Study: SARS-CoV-2 Variants BA.2.86 and JN.1 Show Minimal Immune Evasion

New research from UNC Charlotte's Center for Computational Intelligence to Predict Health and Environmental Risks (CIPHER) has found that the two recent and prevalent strains of the virus that cause COVID-19, SARS-CoV-2 variants BA.2.86 and JN.1, are not significantly better than their predecessor Omicron at evading immune responses and causing infections despite having a high number of mutations compared to Omicron.

22 Jul 2024

Marginal Zone B Cells Unveiled as Key Players in TB Vaccine Strategy

An "unconventional" immune response now identified by scientists from the Hackensack Meridian Center for Discovery and Innovation (CDI) is a potential new pathway for developing new vaccines for tuberculosis (TB), according to a new publication.

16 Jul 2024

Surface Plasmon Resonance Sensors: Transforming Drug Development and Clinical Diagnostics

The latest developments in SPR-based biosensors and their applications in drug discovery.

15 Jul 2024

Scientists develop first fully functional human immune system in mouse model

Researchers at The University of Texas Health Science Center in San Antonio have produced a mouse model that is humanized, complete with a human immune system and a gut microbiome that resembles that of a human being and is able to elicit particular antibody responses.

8 Jul 2024

Discovery Reveals the Role of Interleukin-12 in Directing B-Cell Antibody Responses

B cells are known to generate antibodies through two different responses—an "emergency response" and an "everything is okay, let’s prepare for the future response," says Mark Shlomchik, UPMC Professor and Distinguished Professor of Immunology, University of Pittsburgh School of Medicine.

28 Jun 2024

AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

24 Jun 2024

Antibody News and Research

Further Reading

Early Detection of Off-Target Binding Could Improve Drug Safety

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

One-Third of Antibody Drugs Show Unintended Target Binding

Monoclonal Antibody SC27 Shows Broad Effectiveness Against SARS-CoV-2 Variants

LSTM Research Identifies 91 RNA Viruses in Parasitic Worms

Atypical B Cells Play a Central Role in COVID-19 Vaccine Response

RYBREVANT Receives EC Nod for Advanced Lung Cancer Treatment

A Landmark Study Reveals the Widespread Existence of DNA i-Motifs

New Human Intestinal Immuno-Organoids Reveal Insights into Immune Cell Dynamics and Cancer Immunotherapy

The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

Light-Activated Macrophages Show Increased Appetite for Cancer Cells

Study Challenges Current Understanding of Parkinson's and Lewy Body Disease Onset

Swabbing Technique Reveals Diversity of Immune Cells in the Upper Airway

Antisense Therapy Shows Promise Against Parkinson's

UNC Charlotte Study: SARS-CoV-2 Variants BA.2.86 and JN.1 Show Minimal Immune Evasion

Marginal Zone B Cells Unveiled as Key Players in TB Vaccine Strategy

Surface Plasmon Resonance Sensors: Transforming Drug Development and Clinical Diagnostics

Scientists develop first fully functional human immune system in mouse model

Discovery Reveals the Role of Interleukin-12 in Directing B-Cell Antibody Responses

AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

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