Nuclease News and Research

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Research Details the Food Safety Profile of Genetically Edited Allergen-Free Eggs

Researchers have developed a chicken egg that may be safe for people with egg white allergies. Chicken egg allergies are one of the most common allergies in children.

18 May 2023

Optimized Genome-Editing Method Vastly Reduces Mutations

CRISPR-Cas9 is frequently used to alter the genome by researching and editing disease-related genes. However, this approach is coupled with undesirable side effects including mutations and toxicity.

11 Apr 2023

Researchers expand the known defensive abilities of CRISPR–Cas systems

Viruses can infect bacteria and archaea, just as they can humans. These microbes have evolved their own immune defense mechanisms to combat their pathogens. Bacterial defenses, like CRISPR-Cas systems, contain a variety of proteins and functions that aid bacteria in protecting themselves from foreign intruders.

5 Jan 2023

New CRISPR RNA-guided Caspases could lead to promising antiviral and tissue engineering tools

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

26 Aug 2022

New technology can help detect the activity of CRISPR gene editing tools

Detecting the activity of CRISPR gene editing tools in organisms with the naked eye and an ultraviolet flashlight is now possible using technology developed at the Department of Energy's Oak Ridge National Laboratory.

13 Dec 2021

Study unravels the DNA repair mechanism by enzymes

A new study by researchers from the Gwangju Institute of Science and Technology in the Republic of Korea has revealed the mechanism of DNA repair by enzymes exonuclease III and polymerase I by utilizing single molecule fluorescence resonance energy transfer (smFRET)-enabled dynamic observation.

14 Sep 2021

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

Similar to how a spider traps its prey, the cells of the human immune system cooperate to trap and “eat” bacteria.

14 Sep 2021

Study shows that autophagy plays a key role in messenger RNA degradation

Autophagy is essential in messenger RNA (mRNA) degradation, according to researchers from the Tokyo Institute of Technology (Tokyo Tech).

27 Apr 2021

Study highlights the importance of autophagy in gene regulation

A fine balance between the production and degradation of biomolecules is required for optimal cell function. Autophagy is a mechanism through which cells break down and recycle their own components.

20 Apr 2021

Study reveals mechanisms behind the activation of MRN complex

Researchers from the Tokyo Institute of Technology have revealed mechanisms behind the stimulation of the MRN complex—the DNA scissors of the cells.

11 Mar 2021

New study facilitates the use of gene editing technique on plants

A new study performed by the IBMCP of UPV University enables the use of the CRISPR genomic editing technique on plants.

9 Feb 2021

Newly identified Cas9 nucleases can improve genome editing

Scientists have explained two new compact Cas9 nucleases that will possibly extend the Cas9 toolbox for genome editing.

11 Dec 2020

Researchers determine 3D structures of RNA hybridization with artificial nucleic acids

As medical research progresses, traditional treatment protocols are being rapidly exhausted. New approaches to treat diseases that do not respond to conventional drugs are the need of the hour.

4 Dec 2020

Exploiting CRISPR systems for the fast detection of SARS-CoV-2

A paper published on medRxiv describes a repurposed type III CRISPR-Cas system that can detect the virus from nasopharyngeal swabs in less than an hour.

26 Oct 2020

Researchers develop a series of APOBEC-Cas9 fusion-induced deletion systems

Many small regulatory elements, including miRNAs, miRNA binding sites, and cis-acting elements, comprise only 5~24 nucleotides and play important roles in regulating gene expression, transcription and translation, and protein structure, and thus are promising targets for gene function studies and crop improvement.

1 Jul 2020

New CRISPR technology targets thousands of genes

Thanks to CRISPR-based genetic screens, researchers were able to detect genes that play a major role in lung cancer metastasis, cancer immunotherapy, sickle-cell anemia, and a host of other medical disorders.

18 Mar 2020