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DNA-based nanotransporters could improve treatment of cancers, other diseases

A team of Canadian researchers from Université de Montréal has designed and validated a new class of drug transporters made of DNA that are 20,000 times smaller than a human hair and that could improve how cancers and other diseases are treated.

2 Nov 2022

Molecular responses of Pseudomonas aeruginosa to hydroquinine

Researchers investigating the effects of an organic compound on drug-resistant bacteria found how it can impede and destroy a germ that causes significant illness or even death in some situations.

1 Nov 2022

Metabolite from pomegranate to boost immune cells that fight tumors

Researchers from the Georg-Speyer-Haus in Frankfurt am Main, Germany, and Goethe University Frankfurt have succeeded in developing a new strategy for the treatment of colorectal cancer as part of an interdisciplinary initiative of the LOEWE Center Frankfurt Cancer Institute (FCI).

28 Oct 2022

Immunological mechanisms behind the development of alloantibodies

Hemophilia A is the most frequent severe variant of hemophilia. It nearly mostly affects men. The condition is frequently treatable, although not for all patients. A study at the University of Bonn has now highlighted a critical mechanism required for the therapy to be efficient.

28 Oct 2022

Pioneering gene editing approach could lead to new treatments for CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

From University College London 27 Oct 2022

Salivary miRNAs may be a promising biomarker for persistent post-concussive symptoms in children

Predicting clinical recovery of children with concussion is challenging. While concussion symptoms typically resolve within one to three weeks, up to one-third of children develop persistent post-concussive symptoms (PPCS), including headache, nausea, dizziness, blurred vision and sensitivity to light and/or sound.

26 Oct 2022

A more efficient way to deliver gene therapies to the CNS

For gene therapy, the blood-brain barrier (BBB) poses a formidable obstacle. The BBB, which is made up of cells that are closely packed together, prevents poisons and pathogens from accessing brain tissue while also blocking potential treatments for diseases that impact the CNS.

12 Oct 2022

Adults with congenital blindness experience striking recoveries of night vision after gene therapy

Adults with a genetic form of childhood-onset blindness experienced striking recoveries of night vision within days of receiving an experimental gene therapy, according to researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania.

11 Oct 2022

New insight into human genome evolution

Researchers discovered that in one out of every 4,000 births, some of the genetic code from the mitochondria—the “batteries” that power human cells—inserts itself into the DNA, giving a startling new insight into how humans evolve.

6 Oct 2022

Novel molecules alleviate pain, avoid sedating effect

According to new research headed by UC San Francisco scientists, a newly found group of molecules relieved pain in mice whilst preventing the sedating effect that limits the usage of opiates.

3 Oct 2022

New role for huntingtin protein—neuronal regeneration

A recent study led by the University at Buffalo proposes a novel role for the huntingtin protein (HTT), which leads to Huntington’s disease when mutated.

28 Sep 2022

An inventory of human genetic variation through upgrading the 1000 genomes project resource

The first large-scale WGS project to produce a catalog of human genetic variation was the 1000 Genomes Project (1kGP), which was released as an open-access resource seven years ago.

8 Sep 2022

Simple blood test helps identify patients developing neurotoxic side effects

The treatment of various tumors has been transformed by cell-based immunotherapy, often known as CAR-T cell therapy. To target and combat specific forms of leukemia and lymphoma, the treatment employs genetically engineered T cells.

8 Sep 2022

A “stress test” with a previously unknown gene to revive the exhausted T cells

The task of battling cancer cells can fatigue T cells employed in immunotherapy treatments, or they could shut down once they penetrate tumors. Researchers at the Gladstone Institutes and UC San Francisco have strengthened the therapeutic cells’ resistance via a CRISPR-based edit on their genomes.

30 Aug 2022

BIDMC researchers develop a transformative approach to make more of beige adipose tissues

Once considered an inert tissue, fat – or adipose tissue – is now known to play an active role in the body's critical functions by secreting hormones that regulate hunger and body temperature.

18 Aug 2022

RASTRUM™ - the 3D Printer of Living Cells, Honored in Annual Awards by Leading Business Magazine

RASTRUM™ has taken out the top prize in the Experimental category. RASTRUM™ prints human cells into living tissue models to supercharge research into cancer and other diseases using revolutionary drop-on-demand technology.

From Inventia Life Science 16 Aug 2022

Inventia Life Science Announces Partnership with PhenoVista Biosciences to Accelerate Preclinical Research with 3D Cell Models

Inventia Life Science, a leader in automated generation of complex 3D cell models, and PhenoVista Biosciences, a top provider of custom imaging-based phenotypic assay services, have entered into a partnership to deliver high-content cell-based assay services for drug discovery.

From Inventia Life Science 16 Aug 2022

Mount Sinai and Regeneron Genetics Center launch a large-scale genome sequencing project

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

12 Aug 2022

Researchers identify key molecular differences between initial and metastatic tumors

Researchers at Johns Hopkins Medicine claim to have discovered significant molecular variations between cancer cells that adhere to an initial tumor and those that spread out to develop distant tumors while researching the fatal form of breast cancer known as triple negative.

9 Aug 2022

Researchers report the identification of novel small molecules that stimulate human adaptive immune responses

An antibody that is successfully used to treat a variety of tumors has been replaced with a tiny molecule that researchers from Tel Aviv University and the University of Lisbon have jointly found and manufactured.