Programmed Cell Death News and Research

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Microbes hindering cancer therapy seem to play a bigger role than helpful ones

Melanoma patients receiving therapy that helps their immune system kill cancer cells respond to treatment differently depending on the types of microbes in their gut, and new research suggests the microorganisms hindering therapy have more influence than the beneficial ones.

1 Mar 2022

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

Drug resistance is a major obstacle in the treatment of cancers. In an aggressive type of pancreatic cancer, for instance, drug resistance is associated with the suppression of programmed cell death, which results in the uncontrolled growth of cancer cells.

25 Feb 2022

Study reveals how the body controls inflammation during removal of damaged cells

A research team from Cologne and Osnabrück has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body.

7 Feb 2022

New finding could lead to the development of cell death regulators for cancer therapies

Scientists led by Professor Ana J. Garcia-Saez at the CECAD Cluster of Excellence for Aging Research at the University of Cologne have shown that apoptosis, the programmed cell death, involves a direct physical interplay between the two proteins BAX and DRP1.

17 Jan 2022

Simple, marine-dwelling creature shines light on cancer resistance

A simple, marine-dwelling creature known as Trichoplax adhaerens has some remarkable properties. The organism can tolerate unusually high doses of radiation that would kill most other forms of life. T. adhaerens has another intriguing characteristic: the ability to resist cancer.

24 Dec 2021

Study identifies novel function for existing protein

Researchers recently identified a new role of the protein tBID, which was to date linked to the regulatory role in cancer and cell death. But tBID also directly mediates apoptosis (controlled cell death).

23 Dec 2021

CRISPR introduces potentially dangerous changes in cells, reveals research

New research revealed that gene editing, particularly gene knockout, with CRISPR-Cas9 can support cells with mutated gene forms associated with cancer.

15 Nov 2021

Study identifies protein complex that confers neuroprotection against HSV-1 infection

Recent research by scientists from the University of Illinois demonstrates a process that halts the herpes simplex virus 1 from inducing severe brain damage and death.

15 Oct 2021

High levels of polyunsaturated fatty acids in liver cells linked to hepatitis C virus resistance

Hepatitis C virus thrives in humans for years, damaging the liver by causing chronic inflammation, eventually resulting in cirrhosis and liver cancer.

4 Oct 2021

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

Similar to how a spider traps its prey, the cells of the human immune system cooperate to trap and “eat” bacteria.

14 Sep 2021

Study details the role of PANoptosome in activating innate immune response

Immunologists discovered how immune sensors in infected cells organize and initiate an immune response to infections with living bacteria and viruses.

3 Sep 2021

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

20 Aug 2021

Programmed Cell Death News and Research

Microbes hindering cancer therapy seem to play a bigger role than helpful ones

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

Study reveals how the body controls inflammation during removal of damaged cells

New finding could lead to the development of cell death regulators for cancer therapies

Simple, marine-dwelling creature shines light on cancer resistance

Study identifies novel function for existing protein

CRISPR introduces potentially dangerous changes in cells, reveals research

Study identifies protein complex that confers neuroprotection against HSV-1 infection

High levels of polyunsaturated fatty acids in liver cells linked to hepatitis C virus resistance

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

Study details the role of PANoptosome in activating innate immune response

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

High expression of cell death genes linked to increased risk of dying early from lung cancer

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Antioxidant in green tea may lead to new anti-cancer drugs

Animal model yields important insights into T cell exhaustion

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

Study determines 3D structure of molecular machine involved in placement of key proteins

Protein interactions could serve as therapeutic targets to treat viral infections

New method to improve preclinical evaluation of CAR-T cell therapies

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