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Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.

18 Oct 2021

Researchers improve understanding of molecular mechanisms underlying stomach’s acid pump

Nagoya University researchers and colleagues have improved understanding of the molecular mechanisms of a key protein that makes the stomach acidic. Their findings, published in the journal Nature Communications, could lead to better drugs for stomach ulcers and shed light on the functions of similar proteins across the human body.

15 Oct 2021

Study provides insights on mucin degradation mechanisms by a group of gut bacteria

Recent research identified that a single sulfatase adds to the degradation of mucus that safeguards the intestinal lining.

13 Oct 2021

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.

12 Oct 2021

Study provides novel insights into the breakdown of carminic acid

Carminic acid (a natural red dye extracted from insects) is extensively used in the cosmetic, pharmaceutical, and food industries globally

7 Oct 2021

Active genes do not form clusters and share resources during early development in fruit flies

Active genes do not form clusters and share resources during early development in the fruit fly, according to a new study by New York University and Princeton researchers published in the journal Current Biology.

6 Oct 2021

High levels of polyunsaturated fatty acids in liver cells linked to hepatitis C virus resistance

Hepatitis C virus thrives in humans for years, damaging the liver by causing chronic inflammation, eventually resulting in cirrhosis and liver cancer.

4 Oct 2021

Study finds a correlation between zika-induced neurological complications and Gas6 protein

An article by Brazilian researchers published in the journal Brain, Behavior, and Immunity elucidates one of the mechanisms whereby zika virus causes neurological complications in adult patients and microcephaly in fetuses. The discovery paves the way for future research to develop drugs that combat the virus.

4 Oct 2021

Study pinpoints means to restore the efficacy of drugs for acute myeloid leukemia

Researchers elucidate why certain drugs, in clinical trials, for treating a kind of acute myeloid leukemia often fail and revealed a means to restore their efficacy.

1 Oct 2021

Study develops a highly efficient expression system for high protease yield

Proteases, one of the most inventive products, are utilized to enhance the efficacy of feed additives.

28 Sep 2021

Exploring cell and gene based therapies for Parkinson’s disease

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson's Disease on "Repairing the Parkinsonian Brain," experts highlight some of the current strategies being pursued to restore lost function and replace what is lost in the PD brain, with special emphasis on the challenges associated with translating advanced therapeutic approaches into pioneering clinical trials.

24 Sep 2021

Scientists analyze the molecular machinery of poxviruses at an atomic level

Poxviruses have found a unique way of translating their genes into proteins in the infected organism. A team of researchers from Würzburg shows for the first time how the molecular machinery involved works at an atomic level.

24 Sep 2021

High levels of sulfur volatiles in saliva make children dislike Brassica vegetables

Many children, as well as adults, dislike Brassica vegetables, such as broccoli, cauliflower, cabbage and Brussels sprouts.

23 Sep 2021

Prions may help yeast cope with rapidly changing environmental conditions

Prions are proteins found in the brain and familiar for their role in causing disease.

23 Sep 2021

Researchers provide novel treatment target for common skin condition

Recent research indicates that a familiar inflammatory skin condition might arise due to inadequately regulated sex hormones.

23 Sep 2021

New yeast-bacterium co-culture to synthesize plant hormones for weed control

Plants regulate their growth and development using hormones, including a group called strigolactones that prevent excessive budding and branching.

20 Sep 2021

Scientists discover a new enzymatic complex that can halt cells from aging

Researchers at Université de Montréal and McGill University have discovered a new multi-enzyme complex that reprograms metabolism and overcomes “cellular senescence,” when aging cells stop dividing.

17 Sep 2021

Study opens new avenues for therapies against Charcot-Marie-Tooth disease

CMT, a rare hereditary condition, commences when genetic changes interrupt the transmission of nerve signals from the brain to the muscles of the extremities, specifically those of the lower limbs.

16 Sep 2021

Researchers reveal why nerve cell’s protein production slows down in CMT patients

A team led by MDC researcher Marina Chekulaeva has figured out why protein production slows down in the nerve cells of people suffering from Charcot-Marie-Tooth disease. This discovery could lead to a new therapeutic approach, the scientists report in the journal "Nucleic Acids Research".

16 Sep 2021

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

Similar to how a spider traps its prey, the cells of the human immune system cooperate to trap and “eat” bacteria.

14 Sep 2021

Enzyme News and Research

Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Researchers improve understanding of molecular mechanisms underlying stomach’s acid pump

Study provides insights on mucin degradation mechanisms by a group of gut bacteria

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Study provides novel insights into the breakdown of carminic acid

Active genes do not form clusters and share resources during early development in fruit flies

High levels of polyunsaturated fatty acids in liver cells linked to hepatitis C virus resistance

Study finds a correlation between zika-induced neurological complications and Gas6 protein

Study pinpoints means to restore the efficacy of drugs for acute myeloid leukemia

Study develops a highly efficient expression system for high protease yield

Exploring cell and gene based therapies for Parkinson’s disease

Scientists analyze the molecular machinery of poxviruses at an atomic level

High levels of sulfur volatiles in saliva make children dislike Brassica vegetables

Prions may help yeast cope with rapidly changing environmental conditions

Researchers provide novel treatment target for common skin condition

New yeast-bacterium co-culture to synthesize plant hormones for weed control

Scientists discover a new enzymatic complex that can halt cells from aging

Study opens new avenues for therapies against Charcot-Marie-Tooth disease

Researchers reveal why nerve cell’s protein production slows down in CMT patients

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

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