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Warped immune cell signaling during bile acid exposure may lead to Crohn’s disease

People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects.

8 Apr 2021

Study shows how a subset of T cells is generated in melanoma survivors affected by vitiligo

A few patients suffering from melanoma are known to respond quite well to immunotherapy and experience significant and long-lasting tumor regression.

25 Mar 2021

Protein kinases may offer a solution to treat HIV patients with immunodeficiency

A new study indicates that protein kinases, which initiate the process that erodes the body’s immunity, significantly contribute to the immunodeficiency in HIV patients. Drugs that block these protein kinases may offer a solution to treating HIV patients whose immunity is not restored by antiretroviral therapy.

2 Mar 2021

Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.

10 Feb 2021

Study shows major differences in mild versus severe COVID-19 infection

These days, a crucial question on people’s minds is how long does SARS-CoV-2 immunity last after infection?

22 Jan 2021

Researchers demonstrate potential preventive treatment for Crohn's disease

A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease.

22 Dec 2020

Researchers detect new immune cells that act as major driver of breast cancer growth

Several breast cancer immunotherapies have had only minimal success in treating the aggressive forms of this disease.

17 Dec 2020

Study: DOT1L enzyme is essential for humoral immune responses

Communication, serendipity and an enzyme called DOT1L have all combined to produce some exciting findings into the immune system's B cells and T cells by two groups of Monash Biomedicine Discovery Institute (BDI) scientists.

17 Dec 2020

Scientists successfully edit SIV virus from genomes of non-human primates

Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV - a virus closely related to HIV, the cause of AIDS - from the genomes of non-human primates.

1 Dec 2020

Research sheds light on T cell abnormality in critically ill COVID-19 patients

There is an idea within the coronavirus research field that there is some kind of T cell abnormality in critically ill COVID-19 patients, but specific details have not yet been clarified. To shed light on the problem, a research collaboration based in Kumamoto University (Japan) has performed a genetic analysis of T cells from lung tissue of COVID-19 patients.

23 Nov 2020

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.

17 Nov 2020

MUSC researchers demonstrate polarized Th17 cells can effectively eradicate tumors

Adoptive transfer of T-cells can extend survival and, at times, treat patients with advanced solid tumors.

2 Nov 2020

Novel technique could propel personalized treatments for cancer

When it comes to defeating cancer, some immune cells are mightier than others. But even the best-trained eye and today's advanced scientific tools have trouble discerning the most powerful tumor-fighting cells from the rest.

23 Oct 2020

Study shows antibody-based drug could reduce cancer in mice

Despite the remarkable successes of immune-based treatments for cancer, not everyone responds to these approaches and relapses do occur.

22 Oct 2020

Lymphocytes play crucial role in controlling virus shedding in asymptomatic COVID-19 patients

COVID-19 remains stubbornly inconsistent. More than a million people have died and 35 million have been diagnosed, but a large fraction of people infected with the coronavirus--about 45%, according to recent estimates--show no symptoms at all.

15 Oct 2020

Dynamic map shows how immune cells fight microbes and remember future infections

Scientists have plotted the activity of an unlimited number of genes in the immune cells of mice over the course of an infection.

14 Oct 2020

Study offers new treatment strategies for HIV

According to a new study, immune cells that can detect residual HIV-infected cells in patients living with HIV and undergoing ART continue to remain active.

8 Oct 2020

New Dual CAR T cell immunotherapy can help fight against HIV infection

A recent study published in the journal Nature Medicine, led by researchers James Riley, PhD, a professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania, and Todd Allen, PhD, a professor of Medicine at Harvard Medical School and Group Leader at the Ragon Institute of MGH, MIT and Harvard, describes a new Dual CAR T cell immunotherapy that can help fight HIV infection

24 Sep 2020

New study shows promise for developing COVID-19 vaccine

When news about a novel coronavirus switched from a chronicle of its progress in China to headlines about a worldwide COVID-19 pandemic, Gladstone Institutes scientist Nadia Roan, PhD, was in the midst of publishing several papers on T cells and their role in HIV spread and long-lasting infections.

24 Aug 2020