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Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

Researchers find an epigenetic adaptation showing resistance to targeted therapy in T cell leukemia

Although gene mutations can result in drug resistance, scientists in the Perelman School of Medicine at the University of Pennsylvania have found a vital, non-genetic version that could also boost resistance to targeted treatment in T cell leukemia, which is a kind of blood cell cancer.

3 Mar 2022

Study uncovers genomic drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) is an incurable, rare cancer of skin-homing T cells that is highly disfiguring and lethal at advanced stages.

2 Mar 2022

Protein appears key to the function and survival of brain cells most impacted by glaucoma

A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report.

2 Mar 2022

Researchers discover how pancreatic cells remodel themselves to reduce the immune response in patients at risk for T1D

Scientists have observed for the very first time that insulin-producing cells in the pancreas are attacked by T lymphocytes during the evolution of Type 1 Diabetes.

2 Mar 2022

Researchers study how metabolomic assessment finds postmortem biomarkers indicating decedent’s diabetes mellitus history

One of the most important and difficult aspects of a forensic examination is identifying the cause of death.

2 Mar 2022

Researchers design a new imaging approach to accelerate imaging-based research

A new imaging method has been designed and tested by scientists from Johns Hopkins Medicine.

2 Mar 2022

Men and women do have immune cell differences, study says

Researchers at the La Jolla Institute for Immunology have uncovered novel genes associated with the risk of autoimmune disorders in the CD4+ “helper” T cell subset.

2 Mar 2022

HDO technology found to be effective at silencing problematic genes

T and B lymphocytes, which are part of a group of immune cells commonly called white blood cells, work together to eliminate foreign invaders in the body such as viruses.

1 Mar 2022

Novel molecular pathway shared by ALS and frontotemporal dementia identified

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

1 Mar 2022

Genetics serves a vital role in the way human bodies respond to vaccination and boosters, says study

According to a new study headed by University of Michigan researchers, genetics serve a vital role in the way human bodies respond to vaccinations and booster shots.

25 Feb 2022

New technique uses microscopic magnetic particles to remotely activate brain cells

Scientists at UCL have developed a new technique that uses microscopic magnetic particles to remotely activate brain cells; researchers say the discovery in rats could potentially lead to the development of a new class of non-invasive therapies for neurological disorders.

From University College London 24 Feb 2022

Blood News and Research

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers find an epigenetic adaptation showing resistance to targeted therapy in T cell leukemia

Study uncovers genomic drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma

Protein appears key to the function and survival of brain cells most impacted by glaucoma

Researchers discover how pancreatic cells remodel themselves to reduce the immune response in patients at risk for T1D

Researchers study how metabolomic assessment finds postmortem biomarkers indicating decedent’s diabetes mellitus history

Researchers design a new imaging approach to accelerate imaging-based research

Men and women do have immune cell differences, study says

HDO technology found to be effective at silencing problematic genes

Novel molecular pathway shared by ALS and frontotemporal dementia identified

Genetics serves a vital role in the way human bodies respond to vaccination and boosters, says study

New technique uses microscopic magnetic particles to remotely activate brain cells

Risk variant of COVID-19 decreases risk of contracting HIV by 27%

Study decodes the heterogeneity of tumor-infiltrating immune cell composition in diffuse large B-cell lymphoma

Researchers analyze how natural killer cells respond to COVID-19

Scientists observe first high-resolution 3D image of muscle protein nebulin

Experts identify critical genes that cause coronary heart disease and trigger heart attacks

Experts identify a potential new target for antimalarial development

Study findings open new avenues for research into host-directed therapies for TB

Experts trigger apoptosis in leukemia cells by disrupting their energy maintenance mechanism

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