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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Modifying/Shredding RNA with Small 3D CRISPR Model

Small and precise: these are the perfect traits for CRISPR systems, the Nobel Prize-winning technology used to alter nucleic acids such as RNA and DNA.

28 Sep 2023

New Method That Genetically Modifies Individual Cells in Animals

Researchers at ETH Zurich have created a technique that enables them to genetically alter every animal cell in a unique way.

22 Sep 2023

Broken String Biosciences Closes $15M Series A Funding Round

Broken String Biosciences today announced that it has closed a $15 million Series A investment round, co-led by Illumina Ventures and Mérieux Equity Partners, with contributions from HERAN Partners, and existing investors Tencent and Dieter von Holtzbrinck Ventures.

19 Sep 2023

NICER Gene Editing Technique Reduces Unintended Mutations

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease.

15 Sep 2023

Pusan National University Scientists Explore OsMATL2 Gene as a Candidate for Haploid Induction in Rice

Double haploid technology can dramatically accelerate crop breeding with specifically chosen genetic traits.

13 Sep 2023

The Pathogenic Mechanism Underpinning MEPAN Syndrome

New research published in Nature Metabolism discovered the pathogenic mechanism driving mitochondrial enoyl reductase protein-associated neurodegeneration (MEPAN) syndrome, a rare pediatric neurodegenerative disease.

1 Sep 2023

Scale Biosciences Continues Commercial Expansion with Introduction of New and Differentiated Single Cell Methylation and Single Cell RNA Sequencing Solutions

Scale Biosciences, Inc. (ScaleBioTM), an innovator in single cell sequencing leveraging combinatorial indexing technologies, today announced an expansion of their product portfolio to enable a broader range of single cell omics experiments and unlock new translational research applications.

30 Aug 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

New Gene Editing Technique Reduces Chalkiness in Rice

As global temperatures continue to rise, maintaining the quality and yield of crops adapted to lower temperatures will increasingly become a challenge.

31 Jul 2023

Study Identifies a Gene That Largely Controls Weeping Growth in Apple

Plant geneticists have identified a mutation in a gene that causes the "weeping" architecture – branches growing downwards – in apple trees, a finding that could improve orchard fruit production.

21 Jul 2023

The Function of Stem Cell Barriers in the Treatment of Fertility

A set of molecules controls cells as they proliferate and take on certain identities and spatial placements within a human embryo as it develops.

18 Jul 2023

Using CRISPR to Improve Forest Resilience and Productivity

Researchers at North Carolina State University used a CRISPR gene-editing system to breed poplar trees with reduced levels of lignin, the major barrier to sustainable production of wood fibers, while improving their wood properties.

14 Jul 2023

Gene Recognition of CRISPR-Cas Visualized With New Method

A novel technique has been devised by researchers from the University of Leipzig and the University of Vilnius in Lithuania to monitor the smallest twists and torques of molecules in milliseconds.

13 Jul 2023

Genome of Xerces Blue Butterfly Reveals Extinction Story

The Xerces Blue butterfly (Glaucopsyche xerces) was native to the coastal dunes of San Francisco, in the United States. As the city grew, much of the butterfly's habitat was destroyed and its population was relegated to Golden Gate National Park.

12 Jul 2023

New Culture System may Improve Efficiency and Safety of Genome Editing in HSCs

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

11 Jul 2023

Researchers Develop New Way to Genetically Suppress Malaria-Carrying Mosquitoes

Malaria remains one of the world's deadliest diseases. Each year malaria infections result in hundreds of thousands of deaths, with the majority of fatalities occurring in children under five.

6 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

The First Programmable RNA-Guided System in Eukaryotes Uncovered

Feng Zhang of the Broad Institute at MIT and Harvard and the McGovern Institute for Brain Research at MIT headed a team of researchers who discovered the first programmable RNA-guided mechanism in eukaryotes, which include fungi, plants, and animals.

29 Jun 2023

Albino Squid Illuminates Cephalopod Brain Activity

A team of researchers at the Marine Biological Laboratory (MBL) has successfully engineered an albino strain of Euprymna berryi, the hummingbird bobtail squid.

21 Jun 2023