Genomics

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DSCAM Gene Triplication Causes Excessive Inhibitory Signaling in the Brain of Down Syndrome Mouse

An extra copy of a gene that controls synapse formation in the cortex causes excessive inhibitory signaling and may contribute to Down syndrome, according to a new study publishing April 20th in the open access journal PLOS Biology by Bing Ye of the University of Michigan, US, and colleagues.

21 Apr 2023

Gene-Silencing Complexes Work Together to Render X Chromosomes Inactive

Two protein complexes are involved in the mysterious process of shutting off one X chromosome in female mammals, according to a new study from RIKEN. This result could aid in the understanding of how specific tumors in women develop.

21 Apr 2023

A Previously Unknown Mechanism for DNA Folding Revealed

A hitherto unknown mechanism for DNA folding is described in a study in Nature published by researchers from Karolinska Institutet and the Max Planck Institute for Biophysics.

20 Apr 2023

Adding Few Cell Layers Inside a Corn Kernel Could Increase the Grain's Nutrient Content

What if, by adding a couple of cell layers inside a corn kernel, the grain could become significantly richer in essential nutrients like iron, zinc, and protein? Such an improvement could benefit people who rely on corn for a large portion of their diet, as in many parts of the global south.

20 Apr 2023

Scientists Discover Gene That Plays a Key Role in Determining the Risk for Vascular Diseases

University of School of Medicine researchers have identified a gene that plays a crucial role in determining our risk for heart attacks, deadly aneurysms, coronary artery disease and other dangerous vascular conditions.

19 Apr 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

Augmenting Anatomical EM Images with Multiplexed Gene Expression Maps

Special reporter proteins created by a research team guided by the Technical University of Munich may now aid in molecular discovery.

19 Apr 2023

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

The University of Hong Kong (HKU) School of Biological Sciences research team led by Dr. Gary Ying Wai Chan has uncovered the function of a unique enzyme called ANKLE1.

19 Apr 2023

Genomics Surveillance of Wheat Blast Fungus may be an Effective Disease Management Tool

Pests and diseases may reduce global wheat yields by over 20%. A study published April 11th in the open access journal PLOS Biology by Sergio Latorre at University College London, UK and colleagues suggest that genomic surveillance may be an effective disease management tool with the ability to trace lineages of emerging crop diseases, and to identify genetic traits for breeding disease-resistant lines.

18 Apr 2023

Sickle Cell Disease Cure? Prime Editing Offers Hope for Blood Disorder

At St Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard, researchers have shown how prime editing could help correct the mutation that results in sickle cell disease in a possibly curative method.

18 Apr 2023

Prime Target for Male Contraceptive Development Identified

As far as a highly effective, reversible, and non-hormonal male contraceptive for humans and animals is concerned, the discovery of a gene in multiple mammalian species could set the stage.

18 Apr 2023

New Method Uses Light to Activate Protein Functions

Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail.

18 Apr 2023

A Protein Domain Could Lead to New Treatments for COVID-19

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

18 Apr 2023

Leveraging Advanced Genomic Approaches for Amphibian Conservation

Morris Animal Foundation and Revive & Restore recently announced the funding of five new projects building genomic tools for amphibian conservation.

18 Apr 2023

Genetic Changes Affecting Cartilage Cell Maturation may Influence Adult Height, Study Shows

When it comes to height, our fate is sealed along with our growth plates—cartilage near the ends of bones that hardens as a child develops.

17 Apr 2023

New Tool can Help Untangle Genetic Factors Associated with Shared Characteristics Among Different Species

Aston University has worked with international partners to develop a software package to help scientists answer key questions about genetic factors associated with shared characteristics among different species.

17 Apr 2023

Entry of Aging-Associated Enzymes into Human Genetic Material

An enzyme that controls aging and other metabolic processes accesses human genetic material to modify gene expression within the cell, according to a new study. Images of a sirtuin enzyme bound to a nucleosome, a tightly packed complex of DNA and proteins called histones, have been created by a team led by Penn State researchers.

17 Apr 2023

Rapid Metagenomics: A Powerful Tool for the Diagnosis of Pathogenic Organisms

According to recent research presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark, metagenomic sequencing can also provide quick and actionable antimicrobial resistance predictions to treat bloodstream infections much faster than traditional laboratory tests and has the potential to save lives and help manage antibiotic use (15–18 April 2023).

17 Apr 2023

Researchers Show How a Virus can Induce Cleavage of Human Chromosome 11 to Cause Cancer

The Epstein-Barr virus (EBV) is easily spread through bodily fluids, primarily saliva, such as kissing, shared drinks or using the same eating utensils.

17 Apr 2023

New Clinical RNA Sequencing Platform Helps Facilitate Research into Rare Genetic Conditions

A new clinical RNA sequencing platform at The Hospital for Sick Children (SickKids) is helping to facilitate research into rare genetic conditions and carve a path for Precision Child Health, a movement at SickKids to deliver individualized care for every patient.

17 Apr 2023

Genomics

DSCAM Gene Triplication Causes Excessive Inhibitory Signaling in the Brain of Down Syndrome Mouse

Gene-Silencing Complexes Work Together to Render X Chromosomes Inactive

A Previously Unknown Mechanism for DNA Folding Revealed

Adding Few Cell Layers Inside a Corn Kernel Could Increase the Grain's Nutrient Content

Scientists Discover Gene That Plays a Key Role in Determining the Risk for Vascular Diseases

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

Augmenting Anatomical EM Images with Multiplexed Gene Expression Maps

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

Genomics Surveillance of Wheat Blast Fungus may be an Effective Disease Management Tool

Sickle Cell Disease Cure? Prime Editing Offers Hope for Blood Disorder

Prime Target for Male Contraceptive Development Identified

New Method Uses Light to Activate Protein Functions

A Protein Domain Could Lead to New Treatments for COVID-19

Leveraging Advanced Genomic Approaches for Amphibian Conservation

Genetic Changes Affecting Cartilage Cell Maturation may Influence Adult Height, Study Shows

New Tool can Help Untangle Genetic Factors Associated with Shared Characteristics Among Different Species

Entry of Aging-Associated Enzymes into Human Genetic Material

Rapid Metagenomics: A Powerful Tool for the Diagnosis of Pathogenic Organisms

Researchers Show How a Virus can Induce Cleavage of Human Chromosome 11 to Cause Cancer

New Clinical RNA Sequencing Platform Helps Facilitate Research into Rare Genetic Conditions

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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