Molecular & Structural Biology

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Study indicates a powerful treatment for pulmonary fibrosis

Study indicates a powerful treatment for pulmonary fibrosis

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

7 Aug 2020

Metabolic "switch" may offer clues to increased risk of glucose intolerance in post-menopausal women

Metabolic "switch" may offer clues to increased risk of glucose intolerance in post-menopausal women

Researchers at Tufts University School of Medicine and Tufts Graduate School of Biomedical Sciences have discovered neural mechanisms in mice specific to females that can shift estrogen from playing a protective role in glucose metabolism to one that is disruptive.

7 Aug 2020

Study: Amyloid-beta alters cholesterol biosynthesis in early stages of Alzheimer’s

Study: Amyloid-beta alters cholesterol biosynthesis in early stages of Alzheimer’s

Korea Brain Research Institute (headed by Suh Pann-ghill) announced on July 24 the discovery that an increase in amyloid-beta in the brain alters cholesterol biosynthesis, which was found by Dr. Cheon Mookyung of KBRI through RNA-seq analysis data (omics) using AI.

7 Aug 2020

Researchers develop new models to study molecular characteristics of lung and pancreatic cancers

Researchers develop new models to study molecular characteristics of lung and pancreatic cancers

Scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) report today the development of new models to study molecular characteristics of tumors of the lung and pancreas.

5 Aug 2020

Scientists explore the role of epigenetic regulator factors in embryonic development

Scientists explore the role of epigenetic regulator factors in embryonic development

A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only epigenetically modify its "packaging".

5 Aug 2020

Newly discovered 'mutation fog' linked to normal DNA repair process

Newly discovered 'mutation fog' linked to normal DNA repair process

Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer.

5 Aug 2020

Understanding the dynamics of amyloids is crucial to treat Alzheimer’s and Parkinson’s diseases

Understanding the dynamics of amyloids is crucial to treat Alzheimer’s and Parkinson’s diseases

Even though specific amyloids are found to have a biological function, the formation of amyloids is often linked to Parkinson’s and Alzheimer’s diseases.

5 Aug 2020

New study can help develop longevity-promoting drugs

New study can help develop longevity-promoting drugs

Scientists have successfully dialed up and down the lifespan of creatures by changing the activity of proteins present in roundworm cells.

4 Aug 2020

'Little brain' contains almost 80% of the cerebral cortex’s surface area

'Little brain' contains almost 80% of the cerebral cortex’s surface area

When we say someone has a quick mind, it may be in part thanks to our expanded cerebellum that distinguishes human brains from those of macaque monkeys, for example.

3 Aug 2020

Animals think probabilistically to distinguish contexts, research suggests

Animals think probabilistically to distinguish contexts, research suggests

Among the many things rodents have taught neuroscientists is that in a region called the hippocampus, the brain creates a new map for every unique spatial context - for instance, a different room or maze.

3 Aug 2020

Detailed 3D structure provides a roadmap for tweaking CRISPR-Cas9–guided base editors

Detailed 3D structure provides a roadmap for tweaking CRISPR-Cas9–guided base editors

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy.

31 Jul 2020

Re-engineering antibodies to fight SARS-CoV-2 infection

Re-engineering antibodies to fight SARS-CoV-2 infection

With millions of COVID-19 cases reported across the globe, people are turning to antibody tests to find out whether they have been exposed to the coronavirus that causes the disease.

31 Jul 2020

New and unique class of carbohydrate receptors discovered

New and unique class of carbohydrate receptors discovered

Exopolysaccharides (EPS) are surface-exposed carbohydrates that surround and protect bacteria and are involved in biofilm formation, cell-to-cell interactions, immune evasion, and pathogenesis.

31 Jul 2020

Understanding the structure of SARS-CoV-2 proteins may lead to novel drugs

Understanding the structure of SARS-CoV-2 proteins may lead to novel drugs

COVID-19 is a disease caused by an RNA virus called SARS coronavirus 2 (SARS-CoV-2), that is, a virus that employs RNA to preserve its genetic data.

31 Jul 2020

New methods to regulate enzymes involved in SARS-CoV-2 virus infection

New methods to regulate enzymes involved in SARS-CoV-2 virus infection

A research team from the HSE University has designed innovative methods for controlling the expression of TMPRSS2 and ACE2 enzymes.

30 Jul 2020

A new cell-based gene therapy approach to correct hemophilia A

A new cell-based gene therapy approach to correct hemophilia A

In a new study from the Wake Forest Institute for Regenerative Medicine (WFIRM) researchers have developed an optimized cellular platform for delivering Factor 8 to better treat patients with hemophilia A.

29 Jul 2020

Study may lead to new therapeutic approaches against coronaviruses

Study may lead to new therapeutic approaches against coronaviruses

The immune system secretes an endogenous protein that can strongly suppress coronaviruses, the pathogen that is responsible for causing the current pandemic.

29 Jul 2020

Movement of small RNAs underlies mobile RNA interference

Movement of small RNAs underlies mobile RNA interference

Biologists have known for some time that RNA interference can silence genes in far-off cells. They suspected that a messenger substance “transmits” RNA interference.

29 Jul 2020

'Marie Kondo' enzyme helps fruit fly embryos to clean out maternal proteins

'Marie Kondo' enzyme helps fruit fly embryos to clean out maternal proteins

Researchers at the University of Colorado School of Medicine have discovered a protein in fruit fly embryos, dubbed Marie Kondo, that destroys maternal proteins.

29 Jul 2020

Study reveals efficient expression system for production of coagulation factor XIIIa

Study reveals efficient expression system for production of coagulation factor XIIIa

Many reports illustrate that Coagulation factor XIIIa (FXIIIa) has diverse and crucial functions in thrombus for¬mation and stability.

29 Jul 2020

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