Collagen is a crucial component of the extracellular matrix (ECM), offering low immunogenicity, a porous structure, high permeability, and excellent biocompatibility. These properties support cell viability, adhesion, spreading, proliferation, and differentiation. Low endotoxin ovine collagen solution, derived from sheep, is a highly purified and traceable alternative to bovine or porcine collagen, making it suitable for various biomedical applications due to its low endotoxin levels.
Applications
- 3D bioprinting
- Tissue engineering
- Regenerative medicine
- Drug delivery
- Cell culture, including encapsulation, expansion, and differentiation
Source: Merck
| Product Number |
Description |
| 934070 |
Ovine collagen, 3 mg/ml solution, low endotoxin |
| 934089 |
Ovine collagen, lyophilized, low endotoxin |
| 934100 |
Ovine collagen, maleimide functionalized, low endotoxin |
| 934097 |
Ovine collagen, methacrylate functionalized, low endotoxin |
| 934119 |
Ovine collagen, SPDP functionalized, low endotoxin |
934097 - A polymerizable hydrogel substance called methacrylate-functionalized collagen is made from low endotoxin ovine collagen. The addition of photocrosslinkable methacrylate functional groups makes photopolymerization of biocompatible, biodegradable, and non-immunogenic hydrogels that can encapsulate cells and be used in a variety of biomedical applications possible. In addition, this methacrylate-functionalized collagen is a fantastic substitute for other naturally occurring collagens, like those from bovine or porcine.
934100 - Ovine-derived low endotoxin maleimide functionalized collagen is a great substitute for other naturally derived materials, like those derived from bovine or porcine, and has numerous biomedical applications. Maleimide conjugations are frequently employed to produce covalent conjugates with sulfhydryl molecules.
The click chemistry reaction between thiol and maleimide is frequently employed in bioconjugation due to its dependability, effectiveness, and preference for a chemical reaction at neutral pH. The benefits of the naturally derived collagen are preserved while the PEGylated maleimide functionalization provides simple bioconjugation techniques.
934119 - Minimal endotoxin Ovine collagen that has been functionalized with SPDP can be used to covalently conjugate with molecules that contain sulfhydryl. Collagen with a cleavable disulfide bond is produced when succinimidyl 3-(2-pyridyldithio) propionate (SPDP) reacts with the collagen's primary amine groups or lysine residues. The cleaved linker can interact with different species that have free sulhydryl groups, also known as cysteine residues, which are frequently present in a variety of naturally occurring protein or peptide sequences.