Hyaluronic acid (HA) is a natural polymer found in many extracellular matrices (ECM). Its biocompatibility, biodegradability, and biomimetic characteristics make it one of the most advantageous biopolymers for a myriad of biomedical applications, including tissue engineering, cosmetics, drug delivery, hydrogel development, regenerative medicine, and 3D bioprinting.
Unlike typical HA products that are usually available in sodium salt form, HA in its acid form is soluble in organic solvents like DMSO. This solubility enables a broader range of chemical modifications and functionalization. For example, the carboxylic acid group of glucuronic acid can be modified or functionalized with hydrazine end groups.
Applications
- Biosensors, films, and transdermal microneedles development
- Drug delivery and a carrier of small molecules, large molecules, and biomolecules
- Medical device coatings, wound healing, and cosmetics
- Tissue engineering, including cartilage tissue engineering, bone tissue engineering, and other musculoskeletal tissues
Features and Benefits
- A larger range of chemical modifications and functionalization possibilities
- The same advantages of HA but in acid form
- Soluble in organic solvents such as DMSO