Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Cryo-EM Reveals Structure of GABA Transporter

Using Cryo-EM, a powerful microscopy technique, researchers at IISc and collaborators have decoded the molecular architecture of a transporter protein controlling the movement of a key neurotransmitter.

7 Jul 2023

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

6 Jul 2023

'Purecap' Technique Produces Highly Active mRNA Vaccines with Lower Immunostimulatory Activity

A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA.

6 Jul 2023

Negative Modulation of Arabidopsis Salinity Tolerance by CONSTANS Protein

Arabidopsis (Arabidopsis thaliana)’s photoperiodically controlled flowering and circadian pathways are primarily regulated by CONSTANS (CO), a well-known B-box family member.

5 Jul 2023

Triazoles: A Threat to Wild Birds

According to new research, wild birds living in vineyards are more vulnerable to triazole fungicide contamination than other agricultural landscapes.

5 Jul 2023

New Insight Into the Evolutionary Origins of Phylogenetic Interplay Between Sponges and Microbiome

Over the years, substantial evidence has consistently demonstrated the profound influence of the microbiome, encompassing all microorganisms residing within a living organism, on various vital processes and interactions with their hosts.

5 Jul 2023

Omega-3 Rich Oil Shows Promise in Protecting Honey Bees from Neonicotinoids

New research suggests that the use of an omega-3 rich oil called "ahiflower oil" can prevent damage to honey bee mitochondria caused by neonicotinoid pesticides.

5 Jul 2023

Understanding How Malaria Parasite Modulates Apicoplast Gene Expression

A recent study supported by Tokyo Tech’s World Research Hub Initiative discovered that gene expression within the apicoplast, an organelle in the malaria parasite Plasmodium falciparum, is controlled by melatonin (the circadian signaling hormone) in host blood and intrinsic parasite cues via a factor called ApSigma.

5 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Trim24 Limits the Ability of p53 to Function as a Tumor Suppressor

The tumor suppressor protein p53 has been nicknamed the “guardian of the genome” because it safeguards the DNA from long-term damage or stress by controlling the expression of numerous genes involved in DNA repair, cell division, and cell death.

3 Jul 2023

New AI Tool Tracks Complex Fruit Fly Behavior

What is the easiest way to know if a fruit fly is hungry? Ask a computer.

3 Jul 2023

Ancient Virus-Like Transposons Found to Mediate Horizontal Gene Transfer in Worms

Scientists have known for decades that genes can be transferred from one species to another, both in animals and plants.

30 Jun 2023

Water Fasting Offers Short-Term Weight Loss, But No Long-Term Benefits

Water fasts -; where people consume nothing but water for several days -; might help you lose weight, but it's unclear how long you'll keep it off, according to research from the University of Illinois Chicago.

30 Jun 2023

The First Programmable RNA-Guided System in Eukaryotes Uncovered

Feng Zhang of the Broad Institute at MIT and Harvard and the McGovern Institute for Brain Research at MIT headed a team of researchers who discovered the first programmable RNA-guided mechanism in eukaryotes, which include fungi, plants, and animals.

29 Jun 2023

Mechanisms of MCL-1 Inhibitor-Induced MCL-1 Protein Upregulation and Induction of Apoptosis

A new editorial paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability."

29 Jun 2023

New Study Sets the Stage to Help People Maintain Weight Loss After Dieting

Researchers led by McMaster University professor Gregory Steinberg and postdoctoral research fellow Dongdong Wang have uncovered a key mechanism for promoting weight loss and maintaining the burning of calories during dieting.

29 Jun 2023

Understanding Mammary Biology That May Help Find Therapeutic Targets for Breast Cancer

A new study led by researchers at The University of Texas MD Anderson Cancer, University of California, Irvine and Baylor College of Medicine has created the world's largest and most comprehensive map of normal breast tissue, providing an unprecedented understanding of mammary biology that may help identify therapeutic targets for diseases such as breast cancer.

29 Jun 2023

New Nanoparticle Developed Helps Improve the Delivery of mRNA-Based Vaccines

Johns Hopkins Medicine scientists say they have developed a nanoparticle -; an extremely tiny biodegradable container -; that has the potential to improve the delivery of messenger ribonucleic acid (mRNA)-based vaccines for infectious diseases such as COVID-19, and vaccines for treating non-infectious diseases including cancer.

29 Jun 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

New AI-Assisted Methods to Discover Novel Deaminase Proteins with Unique Functions

At the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, GAO Caixia’s group has introduced the use of artificial intelligence (AI)-assisted techniques to find out novel deaminase proteins with special functions via structural prediction and classification.

28 Jun 2023

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Cryo-EM Reveals Structure of GABA Transporter

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

'Purecap' Technique Produces Highly Active mRNA Vaccines with Lower Immunostimulatory Activity

Negative Modulation of Arabidopsis Salinity Tolerance by CONSTANS Protein

Triazoles: A Threat to Wild Birds

New Insight Into the Evolutionary Origins of Phylogenetic Interplay Between Sponges and Microbiome

Omega-3 Rich Oil Shows Promise in Protecting Honey Bees from Neonicotinoids

Understanding How Malaria Parasite Modulates Apicoplast Gene Expression

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

Trim24 Limits the Ability of p53 to Function as a Tumor Suppressor

New AI Tool Tracks Complex Fruit Fly Behavior

Ancient Virus-Like Transposons Found to Mediate Horizontal Gene Transfer in Worms

Water Fasting Offers Short-Term Weight Loss, But No Long-Term Benefits

The First Programmable RNA-Guided System in Eukaryotes Uncovered

Mechanisms of MCL-1 Inhibitor-Induced MCL-1 Protein Upregulation and Induction of Apoptosis

New Study Sets the Stage to Help People Maintain Weight Loss After Dieting

Understanding Mammary Biology That May Help Find Therapeutic Targets for Breast Cancer

New Nanoparticle Developed Helps Improve the Delivery of mRNA-Based Vaccines

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

New AI-Assisted Methods to Discover Novel Deaminase Proteins with Unique Functions

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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