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Study finds unique molecular mechanism by which Hepatitis C virus evades host’s immune system

Hepatitis C virus (HCV) can cause chronic liver infection, which can lead to irreparable liver damage and liver cancer.

From Osaka University 27 May 2021

Researchers prove that drugs designed for bacteria have the potential to act on human cells

Antibiotics used to treat common bacterial infections may potentially be used to treat human illnesses such as cancer, at least theoretically.

27 May 2021

Neutralizing antibodies are produced after SARS-CoV-2 infection

A research group from Osaka University led by Professor Hisashi Arase and consisting of researchers from the Research Institute for Microbial Diseases, the Institute for Protein Research, the Immunology Frontier Research Center, the Center for Infectious Diseases, and the Graduate School of Medicine has discovered for the first time that both neutralizing antibodies that protect against infection as well as infection-enhancing antibodies that increase infectivity are produced after infection with SARS-CoV-2 by analyzing antibodies derived from COVID-19 patients.

From Osaka University 26 May 2021

Light-controlled on/off switch can help reset the biological clock

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally.

26 May 2021

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Scientists from the UK's University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralize these enzymes.

From University of Bath 26 May 2021

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body's immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim, and Freiburg discovered this mechanism and at the same time identified a way of reactivating the paralyzed immune system to fight the tumor.

25 May 2021

New method helps tests large groups for SARS-CoV-2 infection

Researchers at the Vienna BioCenter designed a testing protocol for SARS-CoV-2 that can process tens of thousands of samples in less than 48 hours. The method, called SARSeq, is published in the journal Nature Communications and could be adapted to many more pathogens.

25 May 2021

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

Alzheimer’s disease is the most prevalent form of dementia distinguished by the accumulation of amyloid plaques in the brain.

24 May 2021

New genetic pathway plays a critical role in the ripening of tomatoes

An international research team has found that a genetic pathway known as CHLORAD, also plays a critical role in the ripening of tomatoes.

24 May 2021

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Self-organizing heart organoids created at the Austrian Academy of Sciences’ Institute of Molecular Biotechnology (IMBA) are also efficient injury and in vitro congenital disease models. These “cardioids” have the potential to transform studies into cardiovascular diseases and heart malformations.

21 May 2021

Three-dimensional organization of genome is extremely dynamic during gamete formation

Inside the nuclei of cells, the genome is tightly organized (packaged). This three-dimensional (3D) genome organization is basic because it controls gene expression.

21 May 2021

Researchers study the origins of life using modern ecological biosignature

While searching for signs of life, scientists often look for chemicals, biosignatures, or phenomena that suggest the presence of current or past life. However, it is not always the case that signs of life on Earth are also signs of life in other planetary ecosystems.

21 May 2021

New iron-nitrogen-doped carbon catalyst could reduce harmful air pollutants

Our reliance on fossil fuels as a primary energy source has pushed air pollution to an all-time high, resulting in several environmental and health concerns. Among the major pollutants, nitrogen oxide (NOx) accumulation can cause severe respiratory diseases and imbalance in the Earth's nitrogen cycle. Reducing NOx accumulation is, therefore, an issue of utmost importance.

21 May 2021

Cell News and Research

Study finds unique molecular mechanism by which Hepatitis C virus evades host’s immune system

Researchers prove that drugs designed for bacteria have the potential to act on human cells

Neutralizing antibodies are produced after SARS-CoV-2 infection

Light-controlled on/off switch can help reset the biological clock

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

Study could help develop peptide siRNA carrier for human oral cancer

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

New method helps tests large groups for SARS-CoV-2 infection

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

New genetic pathway plays a critical role in the ripening of tomatoes

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Three-dimensional organization of genome is extremely dynamic during gamete formation

Researchers study the origins of life using modern ecological biosignature

New iron-nitrogen-doped carbon catalyst could reduce harmful air pollutants

Study shows how mitochondrial function impacts schizophrenia in patients with genetic disorder

Study identifies predictive causal role for specific cell types in type 1 diabetes

High-fat, high-sugar diet reduces intestinal immune cell activity in mice

Study: Turning off molecular switch could help treat melanoma

Successful class of therapeutics attack and shut down unique and harmful genes

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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