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Gut viruses contribute to human health, but provoke inflammation when perturbed

Research in recent years has demonstrated the diverse roles that gut bacteria can play in health and disease, but what about contributions from viruses, which, like bacteria, perpetually reside within the human intestine?

11 Apr 2022

Microcolonies in the GI tract comprise an important niche for cell-cell signaling and plasmid transfer

Published in Nature Communications, research from the University of Minnesota and Mayo Clinic sought to understand how microbial communities help people resist pathogens.

11 Apr 2022

New scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes

A Mount Sinai-led team has developed a reproducible and scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)-;cells that support heart muscle contraction, generated in the lab from human stem cell lines-;which researchers say will improve approaches for disease modeling, regenerative therapies, and drug testing.

8 Apr 2022

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

7 Apr 2022

Study sheds light on genetic causes of Alzheimer’s disease and other dementias

If we want to enhance our knowledge and treatment of Alzheimer’s disease, we need to identify genetic risk factors.

7 Apr 2022

Certain RNA molecules may serve as markers of cellular stress in different diseases

The body's ability to respond to various types of stress is essential for maintaining health, and failure of such adaptive stress responses can trigger or worsen numerous diseases.

6 Apr 2022

Proteins in saliva could serve as a biomarker to identify patients at risk for severe COVID-19

Researchers have identified a family of proteins that is significantly elevated in the saliva of patients hospitalized with COVID-19.

5 Apr 2022

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

4 Apr 2022

High-resolution 3D map reveals cellular structure of the human metathalamus

A new, high-resolution 3D map of a previously unmapped area of the brain has been reconstructed by a team of researchers as part of the Human Brain Project (HBP). The German-based group developed a cytoarchitectonic map (a map of the cellular structure of the brain, down to the individual neurons) of the metathalamus, an area involved in processing audiovisual information.

4 Apr 2022

Researchers discover new type of cell that may play a key role in human lung diseases

A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered by researchers at the Perelman School of Medicine at the University of Pennsylvania.

4 Apr 2022

Researchers discover a unique technique to fight hospital-borne disease

A study team developed an early-stage therapy that sabotages the pump and restores antibiotic efficiency by disclosing the structure of a protein needed by bacteria to pump out antibiotics.

From New York University (NYU) 4 Apr 2022

RNA targeted by small molecule drugs, likely to create new pathways for disease treatment

RNA (ribonucleic acid) is involved in many aspects of human health, and a new study published in the journal Nature provides compelling evidence that RNA could be a promising pharmacological target.

1 Apr 2022

Research offers new insights for cancer patients to avoid developing metastases

This scientific breakthrough, which was published in the science journal Theranostics, might pave the way for cancer patients to prevent developing metastases.

1 Apr 2022

Researchers identify a set of sporadic genetic mutations behind rare brain malformations

A rare type of brain blood vessel malformation known as a cavernous angioma affects more than one million Americans and carries a lifetime risk of stroke and seizures.

31 Mar 2022

Study on key protein offers clues into the origin of mesothelioma

Researchers at the University of Colorado Anschutz Medical Campus and their international collaborators have discovered that a protein critical in the embryonic stages of life is reactivated in certain cases of mesothelioma, offering clues into the origin of this aggressive cancer.

30 Mar 2022

Study reveals genetically driven mucus pathobiology in asthma

A significant amount of genetic risk for asthma is likely mediated through altered gene expression within the airway epithelium.

29 Mar 2022

CAR-T cell treatment via implantable biotechnology more effective in combating cancer

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed an implantable biotechnology that produces and releases CAR-T cells for attacking cancerous tumors.

25 Mar 2022

Tuberculosis causes early epigenetic aging in cells, study finds

In the current study, scientists at Baylor College of Medicine identified that the cells of humans and animals that recovered from tuberculosis had prematurely aged up to 12 to 14 years.

25 Mar 2022

Study uncovers the genetic risk factors for premature aging in pediatric cancer survivors

Variants in two genes have been linked to premature aging in childhood cancer survivors, according to researchers at St. Jude Children’s Research Hospital.

23 Mar 2022

Researchers use urinary proteomics to detect abnormalities inside the body

Dr Jun Qin, a proteomics expert from the State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, and Dr Zhongde Zhang from The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, worked in the front line of compacting COVID-19 disease.

23 Mar 2022

Hospital News and Research

Gut viruses contribute to human health, but provoke inflammation when perturbed

Microcolonies in the GI tract comprise an important niche for cell-cell signaling and plasmid transfer

New scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Study sheds light on genetic causes of Alzheimer’s disease and other dementias

Certain RNA molecules may serve as markers of cellular stress in different diseases

Proteins in saliva could serve as a biomarker to identify patients at risk for severe COVID-19

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

High-resolution 3D map reveals cellular structure of the human metathalamus

Researchers discover new type of cell that may play a key role in human lung diseases

Researchers discover a unique technique to fight hospital-borne disease

RNA targeted by small molecule drugs, likely to create new pathways for disease treatment

Research offers new insights for cancer patients to avoid developing metastases

Researchers identify a set of sporadic genetic mutations behind rare brain malformations

Study on key protein offers clues into the origin of mesothelioma

Study reveals genetically driven mucus pathobiology in asthma

CAR-T cell treatment via implantable biotechnology more effective in combating cancer

Tuberculosis causes early epigenetic aging in cells, study finds

Study uncovers the genetic risk factors for premature aging in pediatric cancer survivors

Researchers use urinary proteomics to detect abnormalities inside the body

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