Induced Pluripotent Stem Cells News and Research

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Novel model system helps studying human ovarian biology

Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab.

22 Feb 2023

New technique could help fine-tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

2 Nov 2022

New guidelines to generate high-quality, well-structured organoids

Researchers have opened a new avenue for investigations of neurological development, disease, and therapies that cannot be undertaken in living people by employing stem cells to grow small brain-like structures in the lab.

30 Sep 2022

Researchers face challenges with stem cell lines that carry major DNA damage

Stem cells are a type of cell that can be configured to transform into almost any sort of cell in the body. They are presently used in research on organ development as well as in the initial phases of embryo development.

15 Aug 2022

Researchers create CAR T cells for cancer immunotherapy

In CAR T-cell immunotherapy, T cells taken from the patient’s own blood are modified to contain so-called chimeric antigen receptors (CAR), which provide the T cells the ability to target and eradicate tumor cells.

8 Aug 2022

Novel model system to identify new treatments for CF patients who continue to struggle without therapies

A mutation in the CFTR gene results in cystic fibrosis (CF). Despite the fact that there are many hundreds of identified mutations, not all of them can now be treated, leaving a sizable portion of CF patients without access to targeted medicines.

3 Aug 2022

Research outlines how stem cells become sensory interneurons

In a first-of-its-kind blueprint, scientists have shown how stem cells mature into sensory interneurons, which are responsible for feelings including touch, pain, and itching.

22 Jul 2022

New 3D in vitro model reveals the origins of human spine

The spinal column is the central supporting structure of the skeleton in all vertebrates. Not only does it provide a place for muscles to attach, it also protects the spinal cord and nerve roots. Defects in its development are known to cause rare hereditary diseases.

28 Apr 2022

SARS-CoV-2 can directly infect a specialized type of kidney cell

The virus that causes COVID-19, SARS-CoV-2, can directly infect a specialized type of kidney cell.

22 Apr 2022

Study explores that extra dosages of genes may lead to surplus X chromosomes

One out of every 500 to 1,000 boys is born with one or more extra X chromosomes, which can cause a variety of symptoms as the extra chromosomes to including infertility, larger breasts, osteoporosis, diabetes, cardiac problems, intellectual incapacity, and cancer.

1 Apr 2022

AI and robotics identify new cellular hallmarks of Parkinson's disease

A study published today in Nature Communications unveils a new platform for discovering cellular signatures of disease that integrates robotic systems for studying patient cells with artificial intelligence methods for image analysis.

28 Mar 2022

Novel molecular pathway shared by ALS and frontotemporal dementia identified

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

1 Mar 2022

Leukemia-on-a-chip; The Future of Preventing Therapy Resistance?

We speak to Dr. Chao Ma, one of the speakers at SLAS 2022, about his groundbreaking 'leukemia-on-a-chip' technology and its future within therapy resistance.

From Society for Laboratory Automation and Screening (SLAS) 27 Jan 2022

Developing Sperm Cells from Primate Stem Cells

We speak to Professor Charles Easley about his latest research into male infertility, and how sperm cells could be potentially developed from primate stem cells.

From University of Georgia 15 Dec 2021

Research offers alternative cell option for organs-on-chips

Organ-on-a-chip technology has provided a push to discover new drugs for a variety of rare and ignored diseases for which current models either don't exist or lack precision. In particular, these platforms can include the cells of a patient, thus resulting in patient-specific discovery.

13 Dec 2021