Lysosomes News and Research

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Anchor proteins inhibit a key metabolic driver involved in cancer and neuronal diseases

Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders.

27 Jan 2021

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

From Osaka University 19 Nov 2020

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.

17 Nov 2020

Scientists reveal molecular mechanism that increases the invasiveness of radioresistant cancer cells

Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.

30 Oct 2020

Enzyme SSH1 impairs disposal of damaged tau and mitochondria leaking toxins

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

13 Oct 2020

Study reveals pathways essential for preventing crystal-induced kidney injury

Human cells are required to work similar to well-oiled machines to maintain the proper function of individuals’ body.

From Osaka University 30 Sep 2020

Researchers identify new therapeutic target for spinocerebellar ataxia

Scientists have created an animal model that simulates cerebellar neurodegeneration and motor dysfunction.

25 Sep 2020

New fluorescent probe to detect damaged mitochondria could help treat neurodegenerative disorders

Scientists have developed a new, multipurpose probe that is capable of detecting the programmed destruction of faulty mitochondria with pinpoint precision.

17 Aug 2020

New method helps track actin involved in mitochondrial dysfunction

The human skeleton helps in moving the body. Similarly, fine skeleton-like filaments inside the cells also help in the movement of cellular structures.

11 Aug 2020

Study reveals the role of embryonic stem cells in cell repair

Chaperone-mediated autophagy (CMA) is a self-eating process that occurs in embryonic stem cells.

27 Jul 2020

New startup launched to overcome the challenge of delivering next-generation therapeutics

Harvard University's Office of Technology Development (OTD) and the Harvard T.H. Chan School of Public Health today announced the launch of Vesigen Therapeutics, a startup company that aims to overcome the challenge of delivering next-generation therapeutics, such as gene-editing complexes, RNA molecules, and other large proteins, to intracellular targets in specific tissues of interest.

23 Jul 2020

TMEM106B gene reveals the causes of neurodegenerative diseases

Across the globe, approximately 50 million people are living with dementia. The two most common forms are Alzheimer's disease and frontotemporal lobar degeneration (FTLD), which develop when neurons in specific parts of the brain stop functioning - triggering memory loss and other behavioral or personality changes.

10 Jul 2020

Princeton researcher solves long-standing mysteries of membrane protein structure

Ion channels and membrane transporters are in the business of moving ions and small molecules across cellular membranes. They are essential for metabolic and cellular homeostasis, and for a host of biological signaling pathways.

30 Jun 2020

Researchers identify osmotic stress as stimulator of cellular waste disposal

Cellular waste disposal, where autophagy and lysosomes interact, performs elementary functions, such as degrading damaged protein molecules, which impair cellular function, and reintroducing the resulting building blocks such as amino acids into the metabolic system.

29 Jun 2020

Protein dynamics can help fight bacterial infections

When pathogenic bacteria infect, the body’s immune system attempts to remove these invaders. One method to do this is to trigger an inflammatory response.

10 Jun 2020

New CRISPR-Cas9 based method for directed protein evolution

"Directed evolution" is the process by which scientists produce tailor-made proteins for cell biology, physiology and biomedicine in the laboratory.

28 May 2020

Pancreatic tumors hijack basic cell mechanism for immune evasion

Pancreatic cancer cells use a normal waste removal process to hide tags on their surfaces that would otherwise let the immune system destroy them, a new study finds. Published online April 22 in Nature, the study results help to answer a longstanding question: why are pancreatic cancers so resistant to immunotherapies, which use the body's own immune defenses to fight cancer?

24 Apr 2020

Sensitive technique makes it possible to study the delivery of RNA drugs

In recent years, RNA molecules, with the ability to affect or turn off pathogenic genes, have become promising drug candidates in several areas.

17 Apr 2020