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Understanding the regulation of intramembrane proteases across the tree of life

Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology.

27 Apr 2022

Study shows the importance of fluid flow in shaping the composition, activity of hydrothermal microbes

Most visitors to Paliochori Beach on the Greek island Milos may not be aware of the bay's shallow-water hydrothermal community, a veritable Greek salad of microbes, that is within snorkeling distance from the shoreline.

25 Apr 2022

Little-known protein may play a role in frontotemporal lobar degeneration

Scientists have known for years that amyloid fibrils -; fibrous, ropelike structures formed by closely linked protein molecules -; are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.

21 Apr 2022

Cryo-EM reveals the structure of fermentation enzyme phosphoketolase

Pharmaceuticals, plastics, and other industries use enzymes to help synthesize molecular feedstocks.

19 Apr 2022

Max Planck researchers reveal the structure of kinetochore corona

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells.

From The Max Planck Institute 11 Apr 2022

Scientists gain fascinating insights into the dynamic ultrastructure of the heart

What happens below the cellular level when the heart contracts and relaxes has long been unexplored. Thanks to new ultra-high-resolution electron microscopy techniques, scientists can now watch the heart beating – almost at a molecular level.

11 Apr 2022

Cryo-EM imaging of STING protein reveals a new binding source for immune attacks

In new research, UT Southwestern scientists report that imaging a key immunity protein known as STING at near-atomic resolution reveals a previously undiscovered binding location that appears to be crucial for launching immunological attacks.

11 Apr 2022

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

7 Apr 2022

Researchers discover a unique technique to fight hospital-borne disease

A study team developed an early-stage therapy that sabotages the pump and restores antibiotic efficiency by disclosing the structure of a protein needed by bacteria to pump out antibiotics.

From New York University (NYU) 4 Apr 2022

Rigaku Pharma Forum 2022 for Advanced Analytical Solutions Used in Industry and Research

Rigaku is proud to be hosting the inaugural Pharma Forum, a free-to-attend, two-day virtual event from April 27-28, 2022. The forum examines a range of analytical techniques and how these can be applied during the development, formulation, and manufacture of pharmaceuticals.

From Rigaku Corporation 4 Apr 2022

Research reveals how a building block protein assembles to form poxvirus scaffold

Researchers at the Okinawa Institute of Science and Technology Graduate University have revealed how poxviruses build their scaffold - a temporary protein coat that forms and disappears as the virus matures.

1 Apr 2022

Plant biologists determine molecular ‘blueprint’, showing how plants observe light

For survival, plants depend on their ability to detect light. Plants, unlike animals, do not have photoreceptors in their eyes to receive and transmit messages from visual inputs.

1 Apr 2022

Multiple nanobodies effectively block infection with different SARS-CoV-2 variants

Researchers at Karolinska Institutet in Sweden have developed a novel strategy for identifying potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants.

28 Mar 2022

Tuberculosis causes early epigenetic aging in cells, study finds

In the current study, scientists at Baylor College of Medicine identified that the cells of humans and animals that recovered from tuberculosis had prematurely aged up to 12 to 14 years.

25 Mar 2022

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

When something unexpected happens with DNA replication, cells call their own form of 911 to stop the process and rectify the problem.

23 Mar 2022

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism.

22 Mar 2022

Researchers use GP2 and UMOD to prevent urinary tract infection

A team led by Karolinska Institute used AI and structural biology to learn more about two similar proteins that protect against bacterial infection in the urinary tract.

16 Mar 2022

Cryo-EM reveals how a bacterial protein senses and rescues stalled ribosomes

As a molecular machine found in the cells of all organisms, the ribosome is responsible for making new proteins.

11 Mar 2022

Study shows that mechanical stress help cancer cells metastasize

A recent study shows that compressing cancer cells through tight spaces makes them more violent and helps them avoid cell death.

9 Mar 2022

Research points to a common thread linking diverse neurodegenerative diseases

Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.

7 Mar 2022