Polymerase News and Research

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Electrochemical biosensor for detecting antibodies

Although it frequently necessitates a challenging laboratory procedure, the quantitative detection of specific antibodies in complex samples like blood can provide information on a variety of diseases.

18 Jan 2023

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Researchers at the Francis Crick Institute, in partnership with Artios, have discovered how an enzyme involved in DNA repair (POLQ) becomes critical to the survival of some tumors when the cancer cells lose the ability to employ a more frequent way of DNA repair.

1 Dec 2022

Revealing the functional significance of DDX41 in great detail

The DDX41 gene encodes the nuclear enzyme DEAD-box-type RNA helicase. Hematopoietic malignancies are caused by DDX41 mutations. However, the mechanism behind the development of this malignancy remains unknown.

21 Nov 2022

Providing structural understanding of the influenza virus

The structure of the influenza replication machinery and how it interacts with cellular proteins have been solved by a team of Oxford University scientists using a variety of techniques at Diamond Light Source.

8 Nov 2022

A strong enzyme that functions similar to a Swiss army knife

Blue-green algae, also known as cyanobacteria, have a superpower that likely contributes to their extreme success as waterway invaders. They have a remarkable capacity to store nitrogen and energy in their cells for use when necessary.

3 Oct 2022

Study highlights the history of ancient DNA technology development

Ancient DNA (aDNA) technology has been used for the past ten years by researchers working under the direction of FU Qiaomei at the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences (CAS) to learn more about the history of ancient human populations, particularly those in East Asia.

26 Jul 2022

Researchers review the major milestones of ancient DNA techniques

Ancient DNA (aDNA) technology has been used for the past ten years by researchers working under the direction of Qiaomei Fu at the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences (CAS) to learn more about the past of ancient human populations, particularly those in East Asia.

25 Jul 2022

Researchers target human protein to combat SARS-CoV-2 and other viruses

People are realizing now, more than two years into the COVID-19 disease outbreak, that the “new normal” will most likely involve practicing to coexist with SARS-CoV-2.

1 Jul 2022

Researchers propose a new fusion method in gene editing to reduce DNA sizes

Researchers who are working on CRISPR/Cas9-mediated gene-editing technology have developed a technique to boost editing performance by reducing DNA deletion sizes.

3 May 2022

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

7 Apr 2022

Researchers show how proteins form DNA-repair mechanism in living bacteria

Two recent research have shown a completely new perspective of how bacterial cells repair broken parts of their DNA (lesions).

From New York University (NYU) 1 Apr 2022

Scientists discover new details on vital enzyme that allows for DNA sequencing

Researchers released a study in Sciences Advances that disclosed new facts about a critical enzyme that allows DNA sequencing.

16 Mar 2022

Researchers discover protein that turbocharges gene response

Researchers are attempting to figure out what happens when our genes are switched “on,” for many years.

From UC San Diego 14 Mar 2022

Sewer slime can accumulate SARS-CoV-2 RNA, study reports

During the COVID-19 pandemic, monitoring the levels of SARS-CoV-2 RNA in wastewater entering treatment plants has been one way that researchers have gauged the disease's spread.

10 Feb 2022

Study provides insight into replication and transcription machinery of ranaviruses

Nucleo-cytoplasmic large DNA viruses (NCLDVs) of the genus Ranavirus (family iridoviridae) have been isolated from aquatic species such as reptiles, amphibians, and bony fish. Poikilotherms are at risk from these promiscuous infections.

21 Jan 2022

Scientists unravel the structure of octopus-like Lassa viral polymerase

Endemic in Western African countries, Lassa virus is transmitted to humans through food or household items that are contaminated with the urine or faeces of Mastomys rats.

7 Dec 2021

Live-cell probes enable visualization of the elongation phase of transcription

A genetically encoded “live-cell” probe developed by scientists from Tokyo Tech pinpointed phosphorylated Ser2 in the enzyme RNA polymerase II.

7 Dec 2021

Scientists test the accuracy of enzymes that copy DNA under weightlessness

Researchers at Queen’s University boarded a modified Falcon 20 aircraft at Ottawa airport on May 22nd, 2019 as part of a scheduled “vomit comet” flight. In this mode of flight, the plane repeatedly climbs in a steep parabola to 8 km, alternating with a freefall descent.

2 Dec 2021

New study shows how neuroblastoma cells deal with rapid division

The cells of a certain tumor type, called neuroblastoma, divide very rapidly. This rapid division can have potentially fatal consequences for them. A new study shows how neuroblastoma cells deal with this dilemma.

1 Dec 2021