Drug Discovery and Manufacturing News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Further Reading

Researchers develop scalable strategy to find novel molecular glue degraders

Researchers develop scalable strategy to find novel molecular glue degraders

Despite immense efforts to improve pharmacology methods, over three-quarters of all human proteins still remain beyond the reach of therapeutic advancement.

5 Aug 2020

New study can help develop longevity-promoting drugs

New study can help develop longevity-promoting drugs

Scientists have successfully dialed up and down the lifespan of creatures by changing the activity of proteins present in roundworm cells.

4 Aug 2020

Understanding the structure of SARS-CoV-2 proteins may lead to novel drugs

Understanding the structure of SARS-CoV-2 proteins may lead to novel drugs

COVID-19 is a disease caused by an RNA virus called SARS coronavirus 2 (SARS-CoV-2), that is, a virus that employs RNA to preserve its genetic data.

31 Jul 2020

Testing COVID-19 with FDA-approved drugs can improve outcomes for affected patients

Testing COVID-19 with FDA-approved drugs can improve outcomes for affected patients

A protein found in viruses that are responsible for causing SARS and COVID-19 infections is virtually identical.

29 Jul 2020

New technology can speed up drug development for tuberculosis

New technology can speed up drug development for tuberculosis

A novel technology that integrates machine learning and high-throughput imaging could accelerate drug discovery to fight tuberculosis (TB).

27 Jul 2020

Substances that target oxytocin receptors can help treat various diseases

Substances that target oxytocin receptors can help treat various diseases

Oxytocin is the so-called “cuddle hormone” or “love hormone” that plays a role in strengthening the relationship between the mother and child and controlling social bonding.

17 Jul 2020

Study can help develop targeted drugs for cancer and other diseases

Study can help develop targeted drugs for cancer and other diseases

In the field of molecular biology, chaperones are a group of proteins that help regulate protein folding. Folding is a significant step in protein synthesis.

1 Jul 2020

Chiral ligands can help develop novel drugs and bioactive compounds

Chiral ligands can help develop novel drugs and bioactive compounds

Numerous therapeutic compounds—such as amino acids, enzymes, and proteins— that are currently available in the market are “chiral compounds.”

1 Jul 2020

Molecular dynamic simulations may contribute to structure-based drug design

Molecular dynamic simulations may contribute to structure-based drug design

Uppsala University scientists have reported that they have developed a new way to predict how unique molecules that can be employed in novel immunotherapy.

26 Jun 2020

Newly designed vesicles can help deliver drugs

Newly designed vesicles can help deliver drugs

Researchers have produced spherical and hollow sacks called vesicles using RNA and protein.

24 Jun 2020

Researchers discover unknown enzyme activity towards human endogenous substrates

Researchers discover unknown enzyme activity towards human endogenous substrates

Scientists have identified an enzymatic activity towards common drugs as well as significant human endogenous substrates, that was previously not known.

24 Jun 2020

Diagnosing Brain Tumors With A Blood Test

Diagnosing Brain Tumors With A Blood Test

A highly sensitive blood test has been found to accurately diagnose and classify different types of brain tumors, resulting in more accurate diagnosis.

23 Jun 2020

New LI383 molecule can help treat opioid-related disorders

New LI383 molecule can help treat opioid-related disorders

A novel molecule LIH383 developed by scientists at the Luxembourg Institute of Health binds to and inhibits a formerly unknown opioid receptor in the brain.

22 Jun 2020

Study shows MMR vaccine may protect against COVID-19 symptoms

Study shows MMR vaccine may protect against COVID-19 symptoms

According to a group of experts, the administration of the MMR vaccine could act as a preventive measure to reduce inflammation linked to COVID-19 infection.

22 Jun 2020

New protein design could help in drug discovery for Parkinson’s disease

New protein design could help in drug discovery for Parkinson’s disease

The neurotransmitter dopamine plays a vital role in everything, starting from motor control to higher cognitive functions, arousal, motivation, sexual gratification, and reinforcement.

12 Jun 2020

Study reveals new insight on vaccines and antimicrobials

Study reveals new insight on vaccines and antimicrobials

Bacteria are known to be versatile living organisms capable of colonizing a wide variety of tissues, hosts, or environments inside a host.

9 Jun 2020

Synthetic molecule suppresses drug cravings with fewer side effects

Synthetic molecule suppresses drug cravings with fewer side effects

A new synthetic molecule selectively reduces the physiological rewards of cocaine in mice.

1 Jun 2020

Making opioids safer and more effective

Making opioids safer and more effective

Dr. John Streicher speaks to AZoLifeSciences about his research on improving opioid drugs to make them safer and more effective.

From University of Arizona 28 May 2020

What If We Could Design Powerful Drugs Without Unwanted Side Effects?

What If We Could Design Powerful Drugs Without Unwanted Side Effects?

Psychedelics have proven effective in treating depression and PTSD, but the medical use of these drugs is limited by their hallucinations.

22 May 2020

A 'Switch' That Turns Autoimmunity Drugs Into Powerful Anti-Cancer Treatments

A 'Switch' That Turns Autoimmunity Drugs Into Powerful Anti-Cancer Treatments

Scientists have discovered a way to transform antibody drugs into antibodies with powerful anti-cancer activity through a simple molecular "switch".

22 May 2020

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