Drug Discovery and Manufacturing News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Further Reading

Non-steroidal anti-inflammatory drugs reduce antibody and inflammatory responses to COVID-19

Non-steroidal anti-inflammatory drugs reduce antibody and inflammatory responses to COVID-19

According to a new study, non-steroidal anti-inflammatory drugs (NSAIDs) decreased both inflammatory and antibody responses to SARS-CoV-2 infection in mice.

26 Jan 2021

Novel compounds may lead to potential treatment for rare terminal childhood illness

Novel compounds may lead to potential treatment for rare terminal childhood illness

Researchers have discovered a method to “rescue” genetically mutated cells, providing opportunities to develop a new treatment for mitochondrial disease.

From University of Exeter 21 Dec 2020

Study demonstrates drug repurposing can be used to treat genetic diseases

Study demonstrates drug repurposing can be used to treat genetic diseases

A new study by researchers at the University of Illinois Chicago describes a potential technique of using drug repurposing for the treatment of genetic diseases.

18 Dec 2020

Scientists identify new target to deliver anti-cancer drugs to tumor cells

Scientists identify new target to deliver anti-cancer drugs to tumor cells

With the evolution of cancer, the quest for identifying efficient treatment techniques for cancer patients has remained challenging.

17 Dec 2020

Study shows metabolic state of disease-causing parasite influences its resistance to drugs

Study shows metabolic state of disease-causing parasite influences its resistance to drugs

A new study has revealed how a disease-causing parasite is able to resist the present range of therapies. The study was recently published in eLife.

2 Dec 2020

Researchers identify potential new treatments for blindness

Researchers identify potential new treatments for blindness

Vision loss associated with inherited genetic disease or aging is predicted to affect as many as 16 million people in the world.

27 Nov 2020

Study shows how drug-like small molecules regulate the activity of ion channels

Study shows how drug-like small molecules regulate the activity of ion channels

Researchers have recently discovered how the function of therapeutically relevant ion channels is regulated by drug-like small molecules.

24 Nov 2020

Interpretable machine learning models create new options for drug discovery

Interpretable machine learning models create new options for drug discovery

Machine learning has been extensively utilized in the chemical sciences for a wide range of processes, including drug design.

19 Nov 2020

New protein imaging technique may lead to advanced tissue analysis

New protein imaging technique may lead to advanced tissue analysis

Researchers have defined a new protein imaging technique that may result in novel discoveries in disease, cell analysis, biological tissue, and more.

18 Nov 2020

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Scientists have determined that drugs meant for treating hepatitis C can block SARS-CoV-2 main protease, which allows reproduction in the novel coronavirus.

17 Nov 2020

New way to predict who will respond to cancer therapies that block Wnt production

New way to predict who will respond to cancer therapies that block Wnt production

Scientists have identified possible means to prognosticate who will respond to cancer therapies that inhibit Wnt production.

16 Nov 2020

Study suggests that melatonin may be a viable treatment option for COVID-19

Study suggests that melatonin may be a viable treatment option for COVID-19

New findings indicate that melatonin could be a potential treatment option for COVID-19.

10 Nov 2020

Study may help develop new antiviral drugs against COVID-19

Study may help develop new antiviral drugs against COVID-19

SARS-CoV-2 is a respiratory virus that is responsible for causing COVID-19 infection. It uses multiple steps to attack the body.

9 Nov 2020

Genetic predispositions affect the efficacy of COVID-19 drugs

Genetic predispositions affect the efficacy of COVID-19 drugs

A paper recently uploaded to bioRxiv* aimed to utilize genome-wide CRISPR screening to identify genes involved in modulating the activity of COVID-19 drugs.

29 Oct 2020

Study sheds new light on penicillin allergy

Study sheds new light on penicillin allergy

Scientists have reported the first strong evidence of the role of HLA-B, a crucial histocompatibility complex gene, in penicillin allergy.

27 Oct 2020

Experimental AI platform predicts best approach to cancer treatment

Experimental AI platform predicts best approach to cancer treatment

The U.S. Food and Drug Administration (FDA) has given final approval to only 4% of all cancer therapeutic drugs being developed.

26 Oct 2020

Statins can reduce risk of heart attacks and other cardiovascular diseases

Statins can reduce risk of heart attacks and other cardiovascular diseases

According to a study recently published in the eLife journal, cholesterol-lowering drugs, known as statins, may lower cancer risk in humans via a pathway unassociated with cholesterol.

15 Oct 2020

Researchers identify specific neurons that may contribute to epileptic seizures

Researchers identify specific neurons that may contribute to epileptic seizures

Epilepsy, results from impairment in brain cells and is often treated with drugs that counteract or control the seizures.

9 Oct 2020

Researchers demonstrate mysterious molecular concept for targeted drug delivery

Researchers demonstrate mysterious molecular concept for targeted drug delivery

Researchers have demonstrated a type of cellular binding that could lead to highly targeted treatments against diseases like cancer.

8 Oct 2020

Study offers new treatment strategies for HIV

Study offers new treatment strategies for HIV

According to a new study, immune cells that can detect residual HIV-infected cells in patients living with HIV and undergoing ART continue to remain active.

8 Oct 2020

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